Early evolution of the T-box transcription factor family

被引:58
|
作者
Sebe-Pedros, Arnau [1 ,2 ]
Ariza-Cosano, Ana [3 ]
Weirauch, Matthew T. [4 ,5 ,6 ]
Leininger, Sven [7 ]
Yang, Ally [8 ,9 ]
Torruella, Guifre [1 ]
Adamski, Marcin [7 ]
Adamska, Maja [7 ]
Hughes, Timothy R. [8 ,9 ]
Luis Gomez-Skarmeta, Jose [3 ]
Ruiz-Trillo, Inaki [1 ,2 ,10 ]
机构
[1] Univ Pompeu Fabra, Consejo Super Invest Cient, Inst Biol Evolut, Barcelona 08003, Spain
[2] Univ Barcelona, Dept Genet, E-08028 Barcelona, Spain
[3] Univ Pablo Olavide Junta Andalucia, Consejo Super Invest Cient, Ctr Andaluz Biol Desarrollo, Seville 41013, Spain
[4] Cincinnati Childrens Hosp Med Ctr, Ctr Autoimmune Genom & Etiol, Cincinnati, OH 45229 USA
[5] Cincinnati Childrens Hosp Med Ctr, Div Rheumatol, Cincinnati, OH 45229 USA
[6] Cincinnati Childrens Hosp Med Ctr, Div Biomed Informat, Cincinnati, OH 45229 USA
[7] Sars Int Ctr Marine Mol Biol, N-5008 Bergen, Norway
[8] Univ Toronto, Terrence Donnelly Ctr, Toronto, ON M5S 3E1, Canada
[9] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 3E1, Canada
[10] Inst Catalana Recerca & Estudis Avancats, Barcelona 08010, Spain
基金
欧洲研究理事会; 加拿大健康研究院;
关键词
origin multicellularity; premetazoan evolution; subfunctionalization; Porifera; Holozoa; XENOPUS-EMBRYOS; BRACHYURY; GENES; BINDING; PROTEIN; EXPRESSION; SPECIFICITY; MESODERM; DOMAINS; FATE;
D O I
10.1073/pnas.1309748110
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Developmental transcription factors are key players in animal multicellularity, being members of the T-box family that are among the most important. Until recently, T-box transcription factors were thought to be exclusively present in metazoans. Here, we report the presence of T-box genes in several nonmetazoan lineages, including ichthyosporeans, filastereans, and fungi. Our data confirm that Brachyury is the most ancient member of the T-box family and establish that the T-box family diversified at the onset of Metazoa. Moreover, we demonstrate functional conservation of a homolog of Brachyury of the protist Capsaspora owczarzaki in Xenopus laevis. By comparing the molecular phenotype of C. owczarzaki Brachyury with that of homologs of early branching metazoans, we define a clear difference between unicellular holozoan and metazoan Brachyury homologs, suggesting that the specificity of Brachyury emerged at the origin of Metazoa. Experimental determination of the binding preferences of the C. owczarzaki Brachyury results in a similar motif to that of metazoan Brachyury and other T-box classes. This finding suggests that functional specificity between different T-box classes is likely achieved by interaction with alternative cofactors, as opposed to differences in binding specificity.
引用
收藏
页码:16050 / 16055
页数:6
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