Rapid 3D Extrusion of Synthetic Tumor Microenvironments

被引：126

作者：

Grolman, Joshua M. ^{[1
]}

Zhang, Douglas ^{[1
]}

Smith, Andrew M. ^{[2
]}

Moore, Jeffrey S. ^{[1
,3
]}

Kilian, Kristopher A. ^{[1
,2
]}

机构：

[1] Univ Illinois, Dept Mat Sci & Engn, Urbana, IL 61801 USA

[2] Univ Illinois, Dept Bioengn, Urbana, IL 61801 USA

[3] Univ Illinois, Dept Chem, Urbana, IL 61801 USA

来源：

ADVANCED MATERIALS | 2015年 / 27卷 / 37期

基金：

美国国家科学基金会;

关键词：

CELL MIGRATION; PARACRINE LOOP; MACROPHAGES; MODELS; CANCER; CULTURE; MICROFIBERS; INSTABILITY; METASTASIS; INVASION;

D O I：

10.1002/adma.201501729

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The spatial positioning of 3D tumor-mimetic microenvironments, containing multiple cell types, is controlled with a simple concentric flow device in a single step. A range of geometric architectures are demonstrated, and the migration of segregated tumor cells and macrophages is explored using drugs that inhibit heterotypic interactions.

引用

页码：5512 / 5517

页数：6

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