Gram-Scale Ketone Synthesis by Direct Reductive Coupling of Alkyl Iodides with Acid Chlorides

被引：19

作者：

Lu, Wenbin ^{[1
]}

Liang, Zhuye ^{[2
]}

Zhang, Yuwei ^{[2
]}

Wu, Fan ^{[1
]}

Qian, Qun ^{[1
]}

Gong, Hegui ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2013年 / 45卷 / 16期

关键词：

nickel; catalysis; ketones; halides; reductions; CATALYZED REACTIONS; HALIDES; ANHYDRIDES; ZINC;

D O I：

10.1055/s-0033-1339297

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkyl aryl ketones were prepared on a gram scale by the nickel-catalyzed reductive coupling of alkyl iodides with aroyl chlorides. When scaled up 30-fold, this reaction shows a comparable coupling efficiency to the previously reported reaction performed under small-scale conditions. The mild and convenient reaction conditions show excellent tolerance to a range of functional groups and provide the ketones in good to excellent yields.

引用

页码：2234 / 2240

页数：7

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