Multifactorial Control of Iteration Events in a Modular Polyketide Assembly Line

被引：29

作者：

Busch, Benjamin ^{[1
]}

Ueberschaar, Nico ^{[1
]}

Behnken, Swantje ^{[1
]}

Sugimoto, Yuki ^{[1
]}

Werneburg, Martina ^{[1
]}

Traitcheva, Nelly ^{[1
]}

He, Jing ^{[1
]}

Hertweck, Christian ^{[1
,2
]}

机构：

[1] Leibniz Inst Nat Stoff Forsch & Infekt Biol, Hans Knoll Inst HKI, Abt Biomol Chem, D-07745 Jena, Germany

[2] Univ Jena, Lehrstuhl Nat Stoffchem, D-07745 Jena, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 20期

关键词：

aureothin; biosynthesis; polyene; polyketide synthase; Streptomyces thioluteus; AUREOTHIN; BIOSYNTHESIS; SYNTHASE;

D O I：

10.1002/anie.201301322

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Freedom and control: First insights into the rare programmed iteration of an individual polyketide synthase (PKS) module were obtained from the analysis and mutation of aureothin (1) synthase. The first ketosynthase (KS) domain primes the PKS, allowing intermediate retrotransfer. Addition of a designated loading module results in a complete loss of iteration. The downstream KS functions as a gatekeeper for correct chain length. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5285 / 5289

页数：5

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