NHC-Catalyzed Reaction of Enals with Hydroxy Chalcones: Diastereoselective Synthesis of Functionalized Coumarins

被引：34

作者：

Bhunia, Anup ^{[1
]}

Patra, Atanu ^{[1
]}

Puranik, Vedavati G. ^{[2
]}

Biju, Akkattu T. ^{[1
]}

机构：

[1] CSIR Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

[2] CSIR Natl Chem Lab, Ctr Mat Characterizat, Pune 411008, Maharashtra, India

来源：

ORGANIC LETTERS | 2013年 / 15卷 / 07期

关键词：

STEREOSELECTIVE-SYNTHESIS; EFFICIENT SYNTHESIS; DIRECT ANNULATIONS; CONJUGATE UMPOLUNG; HOMOENOLATE;

D O I：

10.1021/ol400562z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The N-heterocyclic carbene-catalyzed annulation of enals with 2'-hydroxy chalcones afford cyclopentane-fused coumarin derivatives with an excellent level of diastereocontrol. The reaction tolerates a broad range of functional groups; 25 examples are given, and a preliminary mechanistic investigation is provided.

引用

页码：1756 / 1759

页数：4

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