Ovarian hyperstimulation syndrome after gonadotropin-releasing hormone agonist triggering and "freeze-all": in-depth analysis of genetic predisposition

被引：33

作者：

Santos-Ribeiro, Samuel ^{[1
,2
]}

Polyzos, Nikolaos P. ^{[1
,3
]}

Stouffs, Katrien ^{[4
]}

De Vos, Michel ^{[1
]}

Seneca, Sara ^{[4
]}

Tournaye, Herman ^{[1
]}

Blockeel, Christophe ^{[1
]}

机构：

[1] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Reprod Med, B-1090 Brussels, Belgium

[2] Hosp Univ Santa Maria, Dept Obstet Gynecol & Reprod Med, P-1649035 Lisbon, Portugal

[3] Univ Aarhus, Fac Hlth, Dept Clin Med, DK-8200 Aarhus N, Denmark

[4] Vrije Univ Brussel, Univ Ziekenhuis Brussel, Ctr Med Genet, B-1090 Brussels, Belgium

来源：

JOURNAL OF ASSISTED REPRODUCTION AND GENETICS | 2015年 / 32卷 / 07期

关键词：

GnRH antagonist; Ovarian hyperstimulation syndrome; GnRH agonist triggering; Freeze-all strategy; OHSS-free clinic; FINAL OOCYTE MATURATION; HIGH-RISK PATIENTS; GNRH-AGONIST; ANTAGONIST; OHSS; PREDICTION; WOMEN;

D O I：

10.1007/s10815-015-0498-y

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We report on the results of the whole-genome analysis performed in a patient who developed severe ovarian hyperstimulation syndrome (OHSS) following gonadotropin-releasing hormone (GnRH) agonist triggering in a "freeze-all" protocol. A 30-year-old patient with polycystic ovary syndrome who developed severe early-onset OHSS with clinical ascites, and slight renal and hepatic dysfunction was admitted for monitoring and treatment with cabergoline and intravenous albumin. Exome sequencing to assess for any known genetic predisposition for OHSS was performed. No known genetic variants associated with OHSS predisposition were found. Case reports of severe OHSS following a "freeze-all" strategy are starting to arise, showing that OHSS has not been completely eliminated with this approach. Further studies should be conducted to confirm if such cases may be due to genetic predisposition or not.

引用

页码：1063 / 1068

页数：6

共 39 条

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