Click chemistry at the microscale

被引：21

作者：

Hong, Tingting ^{[1
]}

Liu, Wenfang ^{[1
]}

Li, Ming ^{[2
]}

Chen, Chuanpin ^{[1
]}

机构：

[1] Cent South Univ, Xiangya Sch Pharmaceut Sci, 172 Tongzipo Rd, Changsha 410013, Hunan, Peoples R China

[2] Yangzhou Univ, Sch Environm Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China

来源：

ANALYST | 2019年 / 144卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ONE-POT PREPARATION; MONOLITHIC CAPILLARY COLUMNS; AZIDE-ALKYNE CYCLOADDITIONS; POROUS POLYMER MONOLITHS; CHIRAL STATIONARY-PHASE; ON-A-CHIP; SURFACE FUNCTIONALIZATION; MICROFLUIDIC DEVICES; HYBRID MONOLITHS; GRAPHENE OXIDE;

D O I：

10.1039/c8an01497c

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Click chemistry has attracted tremendous attention for the fabrication of novel microscale systems based on its high reaction efficiency, satisfactory versatility and simple processing. Meanwhile, microscale systems also provide desirable analytical platforms for click reaction study. Herein, we review the employment of click reactions for developing state-of-the-art microchip-based and capillary-based systems. The advantages of innovative off-stoichiometry thiol-ene (OSTE)-microchips, bio-functionalized microchips and monolithic microsystems for chemical and biological assays are highlighted. Moreover, the potential of microscale systems applied for click reaction investigation is indicated as well. This article presents an overview of the recent developments in the combination of microscale systems and click chemistry.

引用

页码：1492 / 1512

页数：21

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