The serotonergic system in ageing and Alzheimer's disease

被引：212
作者：
Julio Rodriguez, Jose [1 ,2 ,3 ,4 ]
Noristani, Harun N. [5 ]
Verkhratsky, Alexei [1 ,2 ,3 ,5 ]
机构：
[1] Basque Fdn Sci, IKERBASQUE, Bilbao 48011, Spain
[2] Hosp Donostia, Inst Invest Sanitaria Biodonostia, San Sebastian 20014, Spain
[3] Ctr Invest Biomed Red Enfermedades Neurodegenerat, San Sebastian 20014, Spain
[4] ASCR, Inst Expt Med, Prague 14220, Czech Republic
[5] Univ Manchester, Fac Life Sci, Manchester, Lancs, England
来源：
PROGRESS IN NEUROBIOLOGY | 2012年 / 99卷 / 01期
基金：
英国生物技术与生命科学研究理事会;
关键词：
Alzheimer's disease; Dementia; Serotonin; Serotonin transporter; Serotonin receptors; Hippocampus; Raphe nucleus; Plasticity; ACUTE TRYPTOPHAN DEPLETION; AGE-RELATED-CHANGES; 5-HT1A RECEPTOR-BINDING; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; NUCLEUS RAPHE DORSALIS; LATE-LIFE DEPRESSION; SERUM VASOCONSTRICTOR SEROTONIN; MILD COGNITIVE IMPAIRMENT; MESSENGER-RNA EXPRESSION;
D O I：
10.1016/j.pneurobio.2012.06.010
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Alzheimer's disease (AD) is one of the major neurodegenerative diseases that deteriorates cognitive functions and primarily affects associated brain regions involved in learning and memory, such as the neocortex and the hippocampus. Following the discovery and establishment of its role as a neurotransmitter, serotonin (5-HT), was found to be involved in a multitude of neurophysiological processes including mnesic function, through its dedicated pathways and interaction with cholinergic, glutamatergic, GABAergic and dopaminergic transmission systems. Abnormal 5-HT neurotransmission contributes to the deterioration of cognitive processes in ageing, AD and other neuropathologies, including schizophrenia, stress, mood disorders and depression. Numerous studies have confirmed the pathophysiological role of the 5-HT system in AD and that several drugs enhancing 5-HT neurotransmission are effective in treating the AD-related cognitive and behavioural deficits. Here we present a comprehensive overview of the role of serotonergic neurotransmission in brain development, maturation and ageing, discuss its role in higher brain function and provide an in depth account of pathological modifications of serotonergic transmission in neurological diseases and AD. (C) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：15 / 41
页数：27
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