One-pot isomerization of aldo-disaccharides to keto-disaccharides in deep sea water under sub-critical conditions

被引：6

作者：

Kulkarni, Aditya ^{[1
]}

Ogata, Makoto ^{[2
]}

Sako, Takeshi ^{[3
]}

Usui, Taichi ^{[1
,2
]}

机构：

[1] Shizuoka Univ, Fac Agr, Dept Appl Biol Chem, Suruga Ward, Shizuoka 4228529, Japan

[2] Shizuoka Univ, Grad Sch Sci & Technol, Dept Biosci, Suruga Ward, Shizuoka 4228529, Japan

[3] Shizuoka Univ, Dept Engn, Naka Ku, Hamamatsu, Shizuoka 4328561, Japan

来源：

TETRAHEDRON LETTERS | 2012年 / 53卷 / 26期

关键词：

Aldo-disaccharide; Keto-disaccharide; Sub-critical water; Sea water; Lactulose; Isomerization; LACTULOSE; EXTRACTION; PRODUCE;

D O I：

10.1016/j.tetlet.2012.04.103

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and facile one-pot isomerization of aldo-disaccharides to keto-disaccharides is achieved by making use of deep sea water in sub-critical conditions. The resulting keto-disaccharides having pharmaceutical and food applications were obtained in modest yields of about 30-32% at the optimum reaction conditions (temperature: 180 degrees C, reaction time: 5 min). Detailed investigation of all major ions in deep sea water revealed that bicarbonate ions play a key role as a catalyst in this isomerization reaction. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：3385 / 3388

页数：4

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