Relationship between polymorphism in the angiotensinogen, angiotensin-converting enzyme or angiotensin II receptor and renal progression in Japanese NIDDM patients

被引:53
作者
Tomino, Y [1 ]
Makita, Y
Shike, T
Gohda, T
Haneda, M
Kikkawa, R
Watanabe, T
Baba, T
Yoshida, H
机构
[1] Juntendo Univ, Sch Med, Dept Med, Div Nephrol, Tokyo 1138421, Japan
[2] Shiga Univ Med Sci, Shiga, Japan
[3] Fukushima Med Coll, Fukushima, Japan
[4] Univ Tokyo, Tokyo, Japan
[5] Tokyo Jikeikai Med Coll, Tokyo, Japan
来源
NEPHRON | 1999年 / 82卷 / 02期
关键词
gene polymorphism; renin-angiotensin system; renal progression; diabetic nephropathy;
D O I
10.1159/000045390
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
We determined the relationship between the gene polymorphism of angiotensinogen (AGT), angiotensin-converting enzyme (ACE), or angiotensin II receptor (AT1R) and the progression of diabetic nephropathy in a multicenter trial of ethnically homogeneous Japanese patients with non-insulin-dependent diabetes (NIDDM). Gene polymorphism of ACE I/D, AGT M235T and AT1R A1166C was determined by polymerase chain reaction amplification using allele-specific primers. Japanese NIDDM patients (n = 1,152) were selected from several diabetic clinics. All patients were divided into three groups as follows: (1) group I (n = 407)1 normoalbuminuric patients; (2) group II (n = 327): microalbuminuric patients, and (3) group III (n = 418): overt albuminuric patients. Clinical factors for investigation in all patients were the date of birth, gender, levels of urinary albumin excretion, findings of the ocular fundus, duration of diabetes, hemoglobin Ale and blood pressure. It appears that genetic polymorphisms in the renin-angiotensin systems, i.e. ACE or AT1R, may affect the progression to renal failure of patients (especially females) with NIDDM.
引用
收藏
页码:139 / 144
页数:6
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