Rates of susceptibility of carbapenems, ceftobiprole, and colistin against clinically important bacteria collected from intensive care units in 2007: Results from the Surveillance of Multicenter Antimicrobial Resistance in Taiwan (SMART)

被引：17

作者：

Jean, Shio-Shin ^{[1
]}

Lee, Wen-Sen ^{[2
]}

Yu, Kwok-Woon ^{[3
]}

Liao, Chun-Hsing ^{[4
]}

Hsu, Chin-Wang ^{[1
]}

Chang, Feng-Yi ^{[5
]}

Ko, Wen-Chien ^{[6
]}

Chen, Ray-Jade ^{[1
]}

Wu, Jiunn-Jong ^{[7
]}

Chen, Yen-Hsu ^{[8
]}

Chen, Yao-Shen ^{[9
]}

Liu, Jien-Wei ^{[10
]}

Lu, Min-Chi ^{[11
]}

Lam, Carlos ^{[1
]}

Liu, Cheng-Yi ^{[12
]}

Hsueh, Po-Ren ^{[13
]}

机构：

[1] Taipei Med Univ, Wan Fang Hosp, Emergency Dept, Dept Emergency & Crit Care Med, Taipei, Taiwan

[2] Taipei Med Univ, Wan Fang Hosp, Div Infect Dis, Dept Internal Med, Taipei, Taiwan

[3] Taipei Vet Gen Hosp, Natl Yang Ming Univ, Dept Internal Med, Pathol & Lab Med, Taipei, Taiwan

[4] Far Eastern Mem Hosp, Dept Internal Med, Taipei, Taiwan

[5] Tri Serv Gen Hosp, Natl Def Med Ctr NDMC, Dept Internal Med, Taipei, Taiwan

[6] Natl Cheng Kung Univ Hosp, Dept Internal Med, Tainan, Taiwan

[7] Natl Cheng Kung Univ Coll Med, Sch Med Technol, Tainan, Taiwan

[8] Kaohsiung Med Univ Hosp, Kaohsiung Med Univ, Coll Med, Grad Inst Med,Dept Internal Med, Kaohsiung, Taiwan

[9] Kaohsiung Vet Gen Hosp, Dept Internal Med, Kaohsiung, Taiwan

[10] Kaohsiung Chang Gung Mem Hosp, Chang Gung Med Coll, Dept Internal Med, Kaohsiung, Taiwan

[11] Chung Shan Med & Dent Univ, Dept Lab Med & Internal Med, Taichung, Taiwan

[12] Taipei Vet Gen Hosp, Div Infect Dis, Dept Internal Med, Taipei, Taiwan

[13] Natl Taiwan Univ Hosp, Dept Lab Med & Internal Med, 7 Chung Shan South Rd, Taipei 100, Taiwan

来源：

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION | 2016年 / 49卷 / 06期

关键词：

carbapenem; ceftobiprole; colistin; intensive care unit; nonsusceptibility; STAPHYLOCOCCUS-AUREUS MRSA; SPECTRUM BETA-LACTAMASES; IN-VITRO ACTIVITY; ERTAPENEM RESISTANCE; IMIPENEM RESISTANCE; VANCOMYCIN; KLEBSIELLA; ENTEROBACTERIACEAE; CEPHALOSPORIN; CEFEPIME;

D O I：

10.1016/j.jmii.2014.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: Data on susceptibility to ceftobiprole and colistin, and the complete evolutionary trends of minimum inhibitory concentrations (MICs) of important carbapenem agents among important pathogens collected in intensive care units (ICUs) in Taiwan are lacking. Methods: We surveyed the MIC distribution patterns of ceftobiprole and colistin and susceptibility profiles of some important pathogens collected from patients hospitalized in intensive care units (ICUs) of major teaching hospitals throughout Taiwan in 2007. We also investigated the rates of nonsusceptibility to powerful carbapenems (imipenem, meropenem) among four important species of Enterobacteriaceae (Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Proteus mirabilis) collected during the same period. MIC breakpoints recommended by the Clinical and Laboratory Standards Institute in 2014 were applied. Results: Colistin showed excellent in vitro activity (susceptibility rate, 96%) against Acinetobacter baumannii isolates but moderate (73-77% susceptibility rate) activity against isolates of Pseudomonas aeruginosa and E. cloacae. The ceftobiprole MIC90 value was 4 mu g/mL for methicillin-resistant Staphylococcus aureus and 16 mu g/mL for P. aeruginosa. The phenotype of methicillin resistance did not markedly increase the MIC value of ceftobiprole among S. aureus isolates. Interestingly, the proportion of isolates that displayed nonsusceptibility to imipenem was significantly higher among P. mirabilis isolates than among isolates of the other three Enterobacteriaceae species, regardless of the production of extended-spectrum beta-lactamase. Conclusion: Continuous monitoring of susceptibility profiles of ICU pathogens to important antibiotics is warranted to provide appropriate antimicrobial regimens against infections in the ICU. Copyright (C) 2015, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC.

引用

页码：969 / 976

页数：8

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