Nigral burden of α-synuclein correlates with striatal dopamine deficit

被引：45

作者：

Kovacs, Gabor G. ^{[1
]}

Milenkovic, Ivan J. ^{[1
]}

Preusser, Matthias ^{[1
]}

Budka, Herbert ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Neurol, A-1097 Vienna, Austria

来源：

MOVEMENT DISORDERS | 2008年 / 23卷 / 11期

关键词：

Parkinson disease; alpha-synuclein; dopamine transporter; striatum; brain imaging;

D O I：

10.1002/mds.22207

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aggregated alpha-synuclein is the hallmark of Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and multiple system atrophy (MSA). Physiologically, alpha-synuclein ensures normal functions of dopamine transporter (DAT) and tyrosine hydoxylase. In alpha-synucleinopathies, it accumulates in neuronal cytoplasm and neurites through several stages. It is unclear whether the accumulation of pathological a-synuclein in the substantia nigra in PI) correlates with the dopaminergic deficit in the striatal target. We evaluated the impact of the nigral burden of pathological alpha-synuclein immunoreactivity in 27 alpha-synucleinopathy brains by morphometric immunohistochemistry. DAT immunoreactivity in the striatum inversely correlates with the total alpha-synuclein burden in the substantia nigra but not with cytoplasmic inclusion counts only. This result has implications for imaging, clinicopathological correlative studies, and staging of the disease process. (C) 2008 Movement Disorder Society.

引用

页码：1608 / 1612

页数：5

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