Synthesis of a 5-alkoxypyrido[3,4-d]pyrimidin-4(3H)-one derivative via directed ortho-metallation of a pyridine analogue

被引：10

作者：

Dishington, AP ^{[1
]}

Johnson, PD ^{[1
]}

Kettle, JG ^{[1
]}

机构：

[1] AstraZeneca, Macclesfield SK10 4TG, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2004年 / 45卷 / 19期

关键词：

amination; DoM; pyridopyrimidine;

D O I：

10.1016/j.tetlet.2004.03.087

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthetic strategy towards a 5-alkoxyprido[3,4-d]pyrimidin-4(3H)-one is described, utilizing palladium catalyzed amination of a bromopyridine, and subsequent directed ortho-metallation/carboxylation as the key steps. (C) 2004 Published by Elsevier Ltd.

引用

页码：3733 / 3735

页数：3

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