Bioreactor design and implementation strategies for the cultivation of filamentous fungi and the production of fungal metabolites: from traditional methods to engineered systems

被引:0
作者
Musoni, Michel [1 ,3 ]
Destain, Jacqueline [1 ]
Thonart, Philippe [1 ,2 ]
Bahama, Jean-Baptiste [3 ]
Delvigne, Frank [1 ]
机构
[1] Univ Liege, Gembloux Agrobio Tech, Ctr Wallon Biol Ind, BE-5030 Gembloux, Belgium
[2] Univ Liege, Serv Technol Microbienne, BE-4000 Liege, Belgium
[3] Univ Burundi, Fac Sci Agron, Lab Protect Vegetaux, Bujumbura, Burundi
来源
BIOTECHNOLOGIE AGRONOMIE SOCIETE ET ENVIRONNEMENT | 2015年 / 19卷 / 04期
关键词
Bioreactors; fungi; secondary metabolites; conidia; solid state fermentation; SOLID-STATE FERMENTATION; TRICHODERMA-HARZIANUM; XYLANASE PRODUCTION; 6-PENTYL-ALPHA-PYRONE PRODUCTION; PROTEASE PRODUCTION; ASPERGILLUS-ORYZAE; HARVEST TIME; ENZYMES; IMPROVEMENT; SUBSTRATE;
D O I
暂无
中图分类号
S3 [农学(农艺学)];
学科分类号
0901 ;
摘要
The production of fungal metabolites and conidia at an industrial scale requires an adequate yield at relatively low cost. To this end, many factors are examined and the design of the bioreactor to be used for the selected product takes a predominant place in the analysis. One approach to addressing the issue is to integrate the scaling-up procedure according to the biological characteristics of the microorganism considered, i.e. in our case filamentous fungi. Indeed, the scaling-up procedure is considered as one of the major bottlenecks in fermentation technology, mainly due to the near impossibility of reproducing the ideal conditions obtained in small reactors designed for research purposes when transposing them to a much larger production scale. The present review seeks to make the point regarding the bioreactor design and its implementation for cultivation of filamentous fungi and the production of fungal metabolites according to different developmental stages of fungi of industrial interest. Solid-state (semi-solid), submerged, fermentation and biofilm reactors are analyzed. The different bioreactor designs used for these three processes are also described at the technological level.
引用
收藏
页码:430 / 442
页数:13
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