Protective Efficacy of a Global HIV-1 Mosaic Vaccine against Heterologous SHIV Challenges in Rhesus Monkeys

被引：296

作者：

Barouch, Dan H. ^{[1
,2
]}

Stephenson, Kathryn E. ^{[1
]}

Borducchi, Erica N. ^{[1
]}

Smith, Kaitlin ^{[1
]}

Stanley, Kelly ^{[1
]}

McNally, Anna G. ^{[1
]}

Liu, Jinyan ^{[1
]}

Abbink, Peter ^{[1
]}

Maxfield, Lori F. ^{[1
]}

Seaman, Michael S. ^{[1
]}

Dugast, Anne-Sophie ^{[2
]}

Alter, Galit ^{[2
]}

Ferguson, Melissa ^{[3
]}

Li, Wenjun ^{[4
]}

Earl, Patricia L. ^{[5
]}

Moss, Bernard ^{[5
]}

Giorgi, Elena E. ^{[6
]}

Szinger, James J. ^{[6
]}

Eller, Leigh Anne ^{[7
]}

Billings, Erik A. ^{[7
]}

Rao, Mangala ^{[7
]}

Tovanabutra, Sodsai ^{[7
]}

Sanders-Buell, Eric ^{[7
]}

Weijtens, Mo ^{[8
]}

Pau, Maria G. ^{[8
]}

Schuitemaker, Hanneke ^{[8
]}

Robb, Merlin L. ^{[7
]}

Kim, Jerome H. ^{[7
]}

Korber, Bette T. ^{[6
]}

Michael, Nelson L. ^{[7
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Ctr Virol & Vaccine Res, Boston, MA 02215 USA

[2] Ragon Inst MGH Massachusetts Inst Technol & Harva, Boston, MA 02114 USA

[3] Alpha Genesis Inc, Yemassee, SC 29945 USA

[4] Univ Massachusetts, Sch Med, Worcester, MA 01605 USA

[5] NIAID, Bethesda, MD 20892 USA

[6] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[7] Walter Reed Army Inst Res, US Mil HIV Res Program, Rockville, MD 20850 USA

[8] Crucell Holland BV, NL-2301 CA Leiden, Netherlands

来源：

CELL | 2013年 / 155卷 / 03期

基金：

美国国家卫生研究院;

关键词：

SIMIAN IMMUNODEFICIENCY VIRUS; T-LYMPHOCYTE RESPONSES; IMMUNE CONTROL; BREADTH; AIDS; IMMUNOGENICITY; DIVERSITY; INFECTION; MACAQUES; COVERAGE;

D O I：

10.1016/j.cell.2013.09.061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The global diversity of HIV-1 represents a critical challenge facing HIV-1 vaccine development. HIV-1 mosaic antigens are bioinformatically optimized immunogens designed for improved coverage of HIV-1 diversity. However, the protective efficacy of such global HIV-1 vaccine antigens has not previously been evaluated. Here, we demonstrate the capacity of bivalent HIV-1 mosaic antigens to protect rhesus monkeys against acquisition of infection following heterologous challenges with the difficult-to-neutralize simian-human immunodeficiency virus SHIV-SF162P3. Adenovirus/poxvirus and adenovirus/adenovirus vector-based vaccines expressing HIV-1 mosaic Env, Gag, and Pol afforded a significant reduction in the per-exposure acquisition risk following repetitive, intrarectal SHIV-SF162P3 challenges. Protection against acquisition of infection correlated with vaccine-elicited binding, neutralizing, and functional nonneutralizing antibodies, suggesting that the coordinated activity of multiple antibody functions may contribute to protection against difficult-to-neutralize viruses. These data demonstrate the protective efficacy of HIV-1 mosaic antigens and suggest a potential strategy for the development of a global HIV-1 vaccine.

引用

页码：531 / 539

页数：9

共 37 条

[1] Comparative seroprevalence and immunogenicity of six rare serotype recombinant adenovirus vaccine vectors from subgroups B and D [J].

Abbink, Peter ;

Lemckert, Angelique A. C. ;

Ewald, Bonnie A. ;

Lynch, Diana M. ;

Denholtz, Matthew ;

Smits, Shirley ;

Holterman, Lennart ;

Damen, Irma ;

Vogels, Ronald ;

Thorner, Anna R. ;

O'Brien, Kara L. ;

Carville, Angela ;

Mansfield, Keith G. ;

Goudsmit, Jaap ;

Havenga, Menzo J. E. ;

Barouch, Dan H. .

JOURNAL OF VIROLOGY, 2007, 81 (09) :4654-4663

[2] A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples [J].

Ackerman, Margaret E. ;

Moldt, Brian ;

Wyatt, Richard T. ;

Dugast, Anne-Sophie ;

McAndrew, Elizabeth ;

Tsoukas, Stephen ;

Jost, Stephanie ;

Berger, Christoph T. ;

Sciaranghella, Gaia ;

Liu, Qingquan ;

Irvine, Darrell J. ;

Burton, Dennis R. ;

Alter, Galit .

JOURNAL OF IMMUNOLOGICAL METHODS, 2011, 366 (1-2) :8-19

[3] Antibody-Mediated Protection against Mucosal Simian-Human Immunodeficiency Virus Challenge of Macaques Immunized with Alphavirus Replicon Particles and Boosted with Trimeric Envelope Glycoprotein in MF59 Adjuvant [J].

Barnett, Susan W. ;

Burke, Brian ;

Sun, Yide ;

Kan, Elaine ;

Legg, Harold ;

Lian, Ying ;

Bost, Kristen ;

Zhou, Fengmin ;

Goodsell, Amanda ;

zur Megede, Jan ;

Polo, John ;

Donnelly, John ;

Ulmer, Jeffrey ;

Otten, Gillis R. ;

Miller, Christopher J. ;

Vajdy, Michael ;

Srivastava, Indresh K. .

JOURNAL OF VIROLOGY, 2010, 84 (12) :5975-5985

[4] Protection of macaques against vaginal SHIV challenge by systemic or mucosal and systemic vaccinations with HIV-envelope [J].

Barnetta, Susan W. ;

Srivastava, Indresh K. ;

Kan, Elaine ;

Zhou, Fengmin ;

Goodsell, Amanda ;

Cristillo, Anthony D. ;

Ferrai, Maria Grazia ;

Weiss, Deborah E. ;

Letvin, Norman L. ;

Montefiori, David ;

Pal, Ranajit ;

Vajdy, Michael .

AIDS, 2008, 22 (03) :339-348

[5] Challenges in the development of an HIV-1 vaccine [J].

Barouch, Dan H. .

NATURE, 2008, 455 (7213) :613-619

[6] Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys [J].

Barouch, Dan H. ;

Liu, Jinyan ;

Li, Hualin ;

Maxfield, Lori F. ;

Abbink, Peter ;

Lynch, Diana M. ;

Iampietro, M. Justin ;

SanMiguel, Adam ;

Seaman, Michael S. ;

Ferrari, Guido ;

Forthal, Donald N. ;

Ourmanov, Ilnour ;

Hirsch, Vanessa M. ;

Carville, Angela ;

Mansfield, Keith G. ;

Stablein, Donald ;

Pau, Maria G. ;

Schuitemaker, Hanneke ;

Sadoff, Jerald C. ;

Billings, Erik A. ;

Rao, Mangala ;

Robb, Merlin L. ;

Kim, Jerome H. ;

Marovich, Mary A. ;

Goudsmit, Jaap ;

Michael, Nelson L. .

NATURE, 2012, 482 (7383) :89-U115

[7] Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys [J].

Barouch, Dan H. ;

O'Brien, Kara L. ;

Simmons, Nathaniel L. ;

King, Sharon L. ;

Abbink, Peter ;

Maxfield, Lori F. ;

Sun, Ying-Hua ;

La Porte, Annalena ;

Riggs, Ambryice M. ;

Lynch, Diana M. ;

Clark, Sarah L. ;

Backus, Katherine ;

Perry, James R. ;

Seaman, Michael S. ;

Carville, Angela ;

Mansfield, Keith G. ;

Szinger, James J. ;

Fischer, Will ;

Muldoon, Mark ;

Korber, Bette .

NATURE MEDICINE, 2010, 16 (03) :319-U116

[8] Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox [J].

Earl, PL ;

Americo, JL ;

Wyatt, LS ;

Eller, LA ;

Whitbeck, JC ;

Cohen, GH ;

Eisenberg, RJ ;

Hartmann, CJ ;

Jackson, DL ;

Kulesh, DA ;

Martinez, MJ ;

Miller, DM ;

Mucker, EM ;

Shamblin, JD ;

Zwiers, SH ;

Huggins, JW ;

Jahrling, PB ;

Moss, B .

NATURE, 2004, 428 (6979) :182-185

[9] Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants [J].

Fischer, Will ;

Perkins, Simon ;

Theiler, James ;

Bhattacharya, Tanmoy ;

Yusim, Karina ;

Funkhouser, Robert ;

Kuiken, Carla ;

Haynes, Barton ;

Letvin, Norman L. ;

Walker, Bruce D. ;

Hahn, Beatrice H. ;

Korber, Bette T. .

NATURE MEDICINE, 2007, 13 (01) :100-106

[10] Distinct Evolutionary Pressures Underlie Diversity in Simian Immunodeficiency Virus and Human Immunodeficiency Virus Lineages [J].

Fischer, Will ;

Apetrei, Cristian ;

Santiago, Mario L. ;

Li, Yingying ;

Gautam, Rajeev ;

Pandrea, Ivona ;

Shaw, George M. ;

Hahn, Beatrice H. ;

Letvin, Norman L. ;

Nabel, Gary J. ;

Korber, Bette T. .

JOURNAL OF VIROLOGY, 2012, 86 (24) :13217-13231

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