Epigenetics and Chromatin Remodeling in Adult Cardiomyopathy

被引：31
作者：
Mahmoud, Salma Awad [1 ]
Poizat, Coralie [1 ,2 ]
机构：
[1] King Faisal Specialist Hosp & Res Ctr, Cardiovasc Res Program, Riyadh 11211, Saudi Arabia
[2] San Diego State Univ, Dept Biol, San Diego, CA 92182 USA
来源：
JOURNAL OF PATHOLOGY | 2013年 / 231卷 / 02期
关键词：
Histone modification; chromatin remodeling; epigenetics; gene regulation; cardiac hypertrophy; adult cardiomyopathy; HISTONE ACETYLTRANSFERASE ACTIVITY; EMBRYONIC STEM-CELLS; PROTEIN-KINASE-C; CARDIAC-HYPERTROPHY; HEART-FAILURE; CARDIOVASCULAR-DISEASE; GENE-EXPRESSION; DNA METHYLATION; SIGNALING PATHWAYS; ADP-RIBOSYLATION;
D O I：
10.1002/path.4234
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The manipulation of chromatin structure regulates gene expression and the flow of genetic information. Histone modifications and ATP-dependent chromatin remodeling together with DNA methylation are dynamic processes that modify chromatin architecture and profoundly modulate gene expression. Their coordinated control is key to ensuring proper cell commitment and organ development, as well as adaption to environmental cues. Recent studies indicate that abnormal epigenetic status of the genome, in concert with alteration of transcriptional networks, contribute to the development of adult cardiomyopathy such as pathological cardiac hypertrophy. Here we consider the emerging role of different classes of chromatin regulators and how their dysregulation in the adult heart alters specific gene programs with subsequent development of major cardiomyopathies. Understanding the functional significance of the different epigenetic marks as points of genetic control may represent a promising future therapeutic tool. (c) 2013 King Faisal Specialist Hospital & Research Centre. Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
引用
收藏
页码：147 / 157
页数：11
相关论文
共 109 条
[1]   UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development [J].
Agger, Karl ;
Cloos, Paul A. C. ;
Christensen, Jesper ;
Pasini, Diego ;
Rose, Simon ;
Rappsilber, Juri ;
Issaeva, Irina ;
Canaani, Eli ;
Salcini, Anna Elisabetta ;
Helin, Kristian .
NATURE, 2007, 449 (7163) :731-U10
[2]   In vivo prevention of adriamycin cardiotoxicity by cyclosporin A or FK506 [J].
Al-Nasser, IA .
TOXICOLOGY, 1998, 131 (2-3) :175-181
[3]   A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression [J].
Anest, V ;
Hanson, JL ;
Cogswell, PC ;
Steinbrecher, KA ;
Strahl, BD ;
Baldwin, AS .
NATURE, 2003, 423 (6940) :659-663
[4]   Ventricular myocytes are not terminally differentiated in the adult mammalian heart [J].
Anversa, P ;
Kajstura, J .
CIRCULATION RESEARCH, 1998, 83 (01) :1-14
[5]   Chromatin signatures of pluripotent cell lines [J].
Azuara, V ;
Perry, P ;
Sauer, S ;
Spivakov, M ;
Jorgensen, HF ;
John, RM ;
Gouti, M ;
Casanova, M ;
Warnes, G ;
Merkenschlager, M ;
Fisher, AG .
NATURE CELL BIOLOGY, 2006, 8 (05) :532-U189
[6]   Environmental exposures, epigenetics and cardiovascular disease [J].
Baccarelli, Andrea ;
Ghosh, Sanjukta .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2012, 15 (04) :323-329
[7]   Control of cardiac growth by histone acetylation/deacetylation [J].
Backs, J ;
Olson, EN .
CIRCULATION RESEARCH, 2006, 98 (01) :15-24
[8]  
Backs J, 2006, J CLIN INVEST, P1
[9]   The δ isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload [J].
Backs, Johannes ;
Backs, Thea ;
Neef, Stefan ;
Kreusser, Michael M. ;
Lehmann, Lorenz H. ;
Patrick, David M. ;
Grueter, Chad E. ;
Qi, Xiaoxia ;
Richardson, James A. ;
Hill, Joseph A. ;
Katus, Hugo A. ;
Bassel-Duby, Rhonda ;
Maier, Lars S. ;
Olson, Eric N. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (07) :2342-2347
[10]   When Signaling Kinases Meet Histones and Histone Modifiers in the Nucleus [J].
Baek, Sung Hee .
MOLECULAR CELL, 2011, 42 (03) :274-284
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