Synthesis and evaluation of phosphorodithioate-based hydrogen sulfide donors

被引：50

作者：

Park, Chung-Min ^{[1
]}

Zhao, Yu ^{[1
]}

Zhu, Zhaohui ^{[2
]}

Pacheco, Armando ^{[1
]}

Peng, Bo ^{[1
]}

Devarie-Baez, Nelmi O. ^{[1
]}

Bagdon, Powell ^{[1
]}

Zhang, Hui ^{[2
]}

Xian, Ming ^{[1
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

[2] Washington State Univ, Coll Pharm, Dept Pharmaceut Sci, Pullman, WA 99164 USA

来源：

MOLECULAR BIOSYSTEMS | 2013年 / 9卷 / 10期

关键词：

FLUORESCENT-PROBES; MOLECULE; BIOCHEMISTRY; BIOLOGY; SULFHYDRATION; CHEMISTRY; CARBON; AGENTS;

D O I：

10.1039/c3mb70145j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of O-aryl- and alkyl-substituted phosphorodithioates were designed and synthesized as hydrogen sulfide (H2S) donors. H2S releasing capability of these compounds was evaluated using fluorescence methods. O-aryl substituted donors showed slow and sustained H2S release while O-alkylated compounds showed very weak H2S releasing capability. We also evaluated donors' protective effects against hydrogen peroxide (H2O2)-induced oxidative damage in myocytes and donors' toxicity toward B16BL6 mouse melanoma cells.

引用

页码：2430 / 2434

页数：5

共 50 条

[1] Synthesis of phosphorodithioate-based hydrogen sulfide donors and their biological effects
Park, Chung-Min
Zhao, Yu
Pacheco, Armando
Peng, Bo
Xian, Ming
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
[2] Use of Phosphorodithioate-Based Compounds as Hydrogen Sulfide Donors
Park, Chung-Min
Xian, Ming
HYDROGEN SULFIDE IN REDOX BIOLOGY, PT A, 2015, 554 : 127 - 142
[3] Evaluation of hydrogen sulfide donors
Benavides, Gloria A.
Squadrito, Giuseppe L.
Huynh, Jimmy J.
Doeller, Jeannette E.
Kraus, David W.
FREE RADICAL BIOLOGY AND MEDICINE, 2007, 43 : S89 - S90
[4] Design and Synthesis of Polymeric Hydrogen Sulfide Donors
Hasegawa, Urara
van der Vlies, Andre J.
BIOCONJUGATE CHEMISTRY, 2014, 25 (07) : 1290 - 1300
[5] Design, Synthesis, and Cardioprotective Effects of N-Mercapto-Based Hydrogen Sulfide Donors
Zhao, Yu
Yang, Chuntao
Organ, Chelsea
Li, Zhen
Bhushan, Shashi
Otsuka, Hiro
Pacheco, Armando
Kang, Jianming
Aguilar, Hector C.
Lefer, David J.
Xian, Ming
JOURNAL OF MEDICINAL CHEMISTRY, 2015, 58 (18) : 7501 - 7511
[6] Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors
Zaorska, Ewelina
Tomasova, Lenka
Koszelewski, Dominik
Ostaszewski, Ryszard
Ufnal, Marcin
BIOMOLECULES, 2020, 10 (02)
[7] Triggered hydrogen sulfide donors
Eckhart, Karoline
Pluth, Michael
Steiger, Andrea
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
[8] Therapeutic potential of hydrogen sulfide donors
Whiteman, Matthew
FREE RADICAL BIOLOGY AND MEDICINE, 2016, 96 : S5 - S5
[9] Organic Isothiocyanates as Hydrogen Sulfide Donors
Martelli, Alma
Citi, Valentina
Testai, Lara
Brogi, Simone
Calderone, Vincenzo
ANTIOXIDANTS & REDOX SIGNALING, 2020, 32 (02) : 110 - 144
[10] Therapeutic outlook for hydrogen sulfide donors
Moore, Philip K.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2013, 31 : S18 - S19

← 1 2 3 4 5 →