Multiple interactions in protein-membrane binding

The myristoylated-alanine-rich C-kinase substrate (MARCKS) protein is an example of a protein with an indefinite native conformation which can participate in multiple binding interactions with surfaces. It is considered as a paradigm for biomolecules interacting with electronic interfaces in electrooptical devices. An approach to theoretically predicting the interfacial interactions is outlined, and its present limitations delineated. Precision optical waveguide lightmode spectroscopy (OWLS) is used to directly measure the kinetics of association and dissociation to lipid-coated metal oxide surfaces mimicking (for example) a FET gate or an optical modulator.