Increased prevalence of primary biliary cirrhosis near superfund toxic waste sites

被引:170
作者
Ala, A
Stanca, CM
Bu-Ghanim, M
Ahmado, I
Branch, AD
Schiano, TD
Odin, JA
Bach, N
机构
[1] CUNY Mt Sinai Sch Med, New York, NY 10029 USA
[2] UCL Royal Free & Univ Coll, Sch Med, London, England
[3] Univ Chicago, Sch Med, Chicago, IL 60637 USA
关键词
D O I
10.1002/hep.21076
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are uncommon liver diseases of unknown etiology. Reported clustering of PBC cases may be due to environmental factors. Individuals with PBC have a high prevalence of thyroid disease and thyroid disease is reportedly more prevalent near Superfund toxic waste sites (SFS). The objective of this study was to examine the prevalence and potential clustering of individuals with PBC and PSC near SFS. De-identified clinical and demographic data were used to determine the observed prevalence for each New York City zip code (n = 174) and borough (n = 5) of patients with PBC (PBC-OLT) or PSC (PSC-OLT) who were listed for liver transplantation. The expected prevalence was calculated using Organ Procurement and Transfer Network (OPTN) and U.S. Census data. Both PBC-OLT patients and patients not listed for liver transplantation (PBC-MSSM) were included in the cluster analysis. Prevalence ratios of PBC-OLT and PSGOLT cases were compared for each zip code and for each borough with regard to the proximity or density of SFS, respectively. SaTScan software was used to identify clusters of PBC-OLT cases and PBC-MSSM cases. Prevalence ratio of PBC-OLT, not PSGOLT, was significantly higher in zip codes containing or adjacent to SFS (1.225 vs. 0.670, respectively, P =.025). The borough of Staten Island had the highest prevalence ratio of PBC-OLT cases and density of SFS. Significant clusters of both PBC-OLT and PBC-MSSM were identified surrounding SFS. In conclusion, toxin exposure may be a risk factor influencing the clustering of PBC cases.
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页码:525 / 531
页数:7
相关论文
共 42 条
[1]   Airborne pollutants and the immune system [J].
Albright, JF ;
Goldstein, RA .
OTOLARYNGOLOGY-HEAD AND NECK SURGERY, 1996, 114 (02) :232-238
[2]   Chemical xenobiotics and mitochondrial autoantigens in primary biliary cirrhosis: Identification of antibodies against a common environmental, cosmetic, and food additive, 2-octynoic acid [J].
Amano, K ;
Leung, PSC ;
Rieger, R ;
Quan, C ;
Wang, XB ;
Marik, J ;
Suen, YF ;
Kurth, MJ ;
Nantz, MH ;
Ansari, AA ;
Lam, KS ;
Zeniya, M ;
Matsuura, E ;
Coppel, RL ;
Gershwin, ME .
JOURNAL OF IMMUNOLOGY, 2005, 174 (09) :5874-5883
[3]   Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible [J].
Amano, K ;
Leung, PSC ;
Xu, QC ;
Marik, J ;
Quan, C ;
Kurth, MJ ;
Nantz, MH ;
Ansari, AA ;
Lam, KS ;
Zeniya, M ;
Coppel, RL ;
Gershwin, ME .
JOURNAL OF IMMUNOLOGY, 2004, 172 (10) :6444-6452
[4]   FAMILIAL PRIMARY BILIARY-CIRRHOSIS [J].
BACH, N ;
SCHAFFNER, F .
JOURNAL OF HEPATOLOGY, 1994, 20 (06) :698-701
[5]   Phenotype analysis of lymphocytes of workers with chronic benzene poisoning [J].
Brandao, MM ;
Rêgo, MAV ;
Pugliese, L ;
Clarêncio, J ;
Bastos, CM ;
Ferreira, J ;
Meyer, R ;
Neves, M ;
Freire, SM .
IMMUNOLOGY LETTERS, 2005, 101 (01) :65-70
[6]   A pharmacokinetic study of occupational and environmental benzene exposure with regard to gender [J].
Brown, EA ;
Shelley, ML ;
Fisher, JW .
RISK ANALYSIS, 1998, 18 (02) :205-213
[7]   Incidence of endocrine disease among residents of New York areas of concern [J].
Carpenter, DO ;
Shen, Y ;
Nguyen, T ;
Le, L ;
Lininger, LL .
ENVIRONMENTAL HEALTH PERSPECTIVES, 2001, 109 :845-851
[8]   The role of the Ah receptor and p38 in Benzo[a]pyrene-7,8-dihydrodiol and Benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide-induced apoptosis [J].
Chen, SJ ;
Nguyen, N ;
Tamura, K ;
Karin, M ;
Tukey, RH .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (21) :19526-19533
[9]   Analysis of the geographical distribution of sporadic Creutzfeldt-Jakob disease in France between 1992 and 1998 [J].
d'Aignaux, JH ;
Cousens, SN ;
Delasnerie-Lauprêtre, N ;
Brandel, JP ;
Salomon, D ;
Laplanche, JL ;
Hauw, JJ ;
Alpérovitch, A .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2002, 31 (02) :490-495
[10]   HIGH PREVALENCE OF SEROIMMUNOLOGIC ABNORMALITIES IN RELATIVES OF PATIENTS WITH ACTIVE CHRONIC HEPATITIS OR PRIMARY BILIARY-CIRRHOSIS [J].
GALBRAITH, RM ;
SMITH, M ;
MACKENZIE, RM ;
TEE, DE ;
DONIACH, D ;
WILLIAMS, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1974, 290 (02) :63-69