共 42 条
Increased prevalence of primary biliary cirrhosis near superfund toxic waste sites
被引:170
作者:

Ala, A
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机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Stanca, CM
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机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Bu-Ghanim, M
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机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Ahmado, I
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机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Branch, AD
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机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Schiano, TD
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h-index: 0
机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Odin, JA
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h-index: 0
机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA

Bach, N
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机构: CUNY Mt Sinai Sch Med, New York, NY 10029 USA
机构:
[1] CUNY Mt Sinai Sch Med, New York, NY 10029 USA
[2] UCL Royal Free & Univ Coll, Sch Med, London, England
[3] Univ Chicago, Sch Med, Chicago, IL 60637 USA
来源:
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D O I:
10.1002/hep.21076
中图分类号:
R57 [消化系及腹部疾病];
学科分类号:
摘要:
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are uncommon liver diseases of unknown etiology. Reported clustering of PBC cases may be due to environmental factors. Individuals with PBC have a high prevalence of thyroid disease and thyroid disease is reportedly more prevalent near Superfund toxic waste sites (SFS). The objective of this study was to examine the prevalence and potential clustering of individuals with PBC and PSC near SFS. De-identified clinical and demographic data were used to determine the observed prevalence for each New York City zip code (n = 174) and borough (n = 5) of patients with PBC (PBC-OLT) or PSC (PSC-OLT) who were listed for liver transplantation. The expected prevalence was calculated using Organ Procurement and Transfer Network (OPTN) and U.S. Census data. Both PBC-OLT patients and patients not listed for liver transplantation (PBC-MSSM) were included in the cluster analysis. Prevalence ratios of PBC-OLT and PSGOLT cases were compared for each zip code and for each borough with regard to the proximity or density of SFS, respectively. SaTScan software was used to identify clusters of PBC-OLT cases and PBC-MSSM cases. Prevalence ratio of PBC-OLT, not PSGOLT, was significantly higher in zip codes containing or adjacent to SFS (1.225 vs. 0.670, respectively, P =.025). The borough of Staten Island had the highest prevalence ratio of PBC-OLT cases and density of SFS. Significant clusters of both PBC-OLT and PBC-MSSM were identified surrounding SFS. In conclusion, toxin exposure may be a risk factor influencing the clustering of PBC cases.
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页码:525 / 531
页数:7
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