A selective aptameric sequence is adsorbed on a two-dimensional nanostructured metallic platform optimized for surface-enhanced Raman spectroscopy (SERS) measurements. Using nanofabrication methods, a metallic nanostructure was prepared by electron-beam lithography onto a glass coverslip surface and embedded within a microfluidic channel made of polydimethylsiloxane, allowing one to monitor in situ SERS fingerprint spectra from the adsorbed molecules on the metallic nanostructures. The gold structure was designed so that its localized surface plasmon resonance matches the excitation wavelength used for the Raman measurement. This optofluidic device is then used to detect the presence of a toxin, namely ochratoxin-A (OTA), in a confined environment, using very small amounts of chemicals, and short data acquisition times, by taking advantage of the optical properties of a SERS platform to magnify the Raman signals of the aptameric monolayer system and avoiding chemical labeling of the aptamer or the OTA target.
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页码:1613 / 1621
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Zhang J, 2008, SMALL, V4, P1196, DOI 10.1002/smll.200800057
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Zhu, Zhenyu
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Schmidt, Thomas
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Schmidt, Thomas
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Mahrous, Maroi
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Mahrous, Maroi
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Guieu, Valerie
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Guieu, Valerie
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Perrier, Sandrine
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Perrier, Sandrine
;
Ravelet, Corinne
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Ravelet, Corinne
;
Peyrin, Eric
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
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Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Zhu, Zhenyu
;
Ravelet, Corinne
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Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Ravelet, Corinne
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Perrier, Sandrine
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Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Perrier, Sandrine
;
Guieu, Valerie
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Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Guieu, Valerie
;
Roy, Beatrice
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Univ Montpellier 2, CNRS, UMR 5247, Inst Biomol Max Mousseron, Montpellier, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Roy, Beatrice
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Perigaud, Christian
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Univ Montpellier 2, CNRS, UMR 5247, Inst Biomol Max Mousseron, Montpellier, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Perigaud, Christian
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Peyrin, Eric
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Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
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Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
Zuo, Xiaolei
;
Xiao, Yi
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Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
Xiao, Yi
;
Plaxco, Kevin W.
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Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Program BioMol Sci & Engn, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Zhu, Zhenyu
;
Schmidt, Thomas
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Schmidt, Thomas
;
Mahrous, Maroi
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Mahrous, Maroi
;
Guieu, Valerie
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Guieu, Valerie
;
Perrier, Sandrine
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Perrier, Sandrine
;
Ravelet, Corinne
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
Ravelet, Corinne
;
Peyrin, Eric
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Univ Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, FranceUniv Grenoble 1, Dept Pharmacochim Mol, CNRS, UMR 5063,ICMG,FR 2607, F-38402 St Martin Dheres, France
机构:
Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Zhu, Zhenyu
;
Ravelet, Corinne
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机构:
Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Ravelet, Corinne
;
Perrier, Sandrine
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机构:
Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Perrier, Sandrine
;
Guieu, Valerie
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机构:
Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Guieu, Valerie
;
Roy, Beatrice
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h-index: 0
机构:
Univ Montpellier 2, CNRS, UMR 5247, Inst Biomol Max Mousseron, Montpellier, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Roy, Beatrice
;
Perigaud, Christian
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h-index: 0
机构:
Univ Montpellier 2, CNRS, UMR 5247, Inst Biomol Max Mousseron, Montpellier, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
Perigaud, Christian
;
Peyrin, Eric
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h-index: 0
机构:
Univ Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, FranceUniv Grenoble 1, CNRS, ICMG FR 2607, UMR 5063,Dept Pharmacochim Mol, F-38402 St Martin Dheres, France
机构:
Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
Zuo, Xiaolei
;
Xiao, Yi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Dept Mech Engn, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
Xiao, Yi
;
Plaxco, Kevin W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA
Univ Calif Santa Barbara, Program BioMol Sci & Engn, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA