18F-DOPA PET/CT But Not 68Ga-DOTA-TOC PET/CT Revealed the Underlying Cause of Ectopic Cushing Syndrome

被引：12

作者：

Schalin-Jantti, Camilla ^{[1
,2
]}

Ahonen, Aapo ^{[3
,4
]}

Seppanen, Marko ^{[5
,6
]}

机构：

[1] Univ Helsinki, Inst Clin Med, Div Endocrinol, FI-00290 Helsinki, Finland

[2] Helsinki Univ Hosp, Dept Med, Div Endocrinol, Helsinki, Finland

[3] Helsinki Univ Hosp, Dept Nucl Med, Div Endocrinol, Helsinki, Finland

[4] Helsinki Univ Hosp, Helsinki PET Ctr, Helsinki, Finland

[5] Turku Univ Hosp, Dept Nucl Med, FIN-20520 Turku, Finland

[6] Turku Univ Hosp, Turku PET Ctr, FIN-20520 Turku, Finland

来源：

CLINICAL NUCLEAR MEDICINE | 2012年 / 37卷 / 09期

关键词：

ectopic Cushing syndrome; LCNEC; NET; neuroendocrine carcinoma; ectopic ACTH; imaging; CT; PET; TOMOGRAPHY; DIAGNOSIS; TUMORS;

D O I：

10.1097/RLU.0b013e318262adc7

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

F-18-DOPAPET/CT but not Ga-68-DOTA-TOC PET/CT revealed the cause of ectopic Cushing syndrome in a 61-year-old man. The patient presented with rapid weight gain, swollen legs, and sleep disturbances. Plasma potassium level was 2.7 mM (reference range, 3.3-4.9 mM), 24-hour urinary cortisol level was 13,124 nmol (reference range, 30-144 nmol), and plasma adrenocorticotropin level was 61 ng/L (reference range, <48 g/L). CT demonstrated prominent lymph nodes in the left lung hilus and hyperplastic adrenals but no primary tumor. Ga-68-DOTA-TOC PET/CT, which is recommended as the first-line PET imaging, was performed, but it was not diagnostic. Imaging with F-18-DOPA PET/CT revealed the underlying cause.

引用

页码：904 / 905

页数：2

共 9 条

[1] The ectopic ACTH syndrome [J].

Alexandraki, Krystallenia I. ;

Grossman, Ashley B. .

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS, 2010, 11 (02) :117-126

[2] Comparison between 68Ga-DOTA-NOC and 18F-DOPA PET for the detection of gastro-entero-pancreatic and lung neuro-endocrine tumours [J].

Ambrosini, Valentina ;

Tomassetti, Paola ;

Castellucci, Paolo ;

Campana, Davide ;

Montini, Giancarlo ;

Rubello, Domenico ;

Nanni, Cristina ;

Rizzello, Anna ;

Franchi, Roberto ;

Fanti, Stefano .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2008, 35 (08) :1431-1438

[3] Developments in PET for the detection of endocrine tumours [J].

Eriksson, B ;

Örlefors, H ;

Öberg, K ;

Sundin, A ;

Bergström, M ;

Långström, B .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 19 (02) :311-324

[4] The ectopic adrenocorticotropin syndrome: Clinical features, diagnosis, management, and long-term follow-up [J].

Isidori, AM ;

Kaltsas, GA ;

Pozza, C ;

Frajese, V ;

Newell-Price, J ;

Reznek, RH ;

Jenkins, PJ ;

Monson, JP ;

Grossman, AB ;

Besser, GM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2006, 91 (02) :371-377

[5] The clinical value of [18F]fluoro-dihydroxyphenylalanine positron emission tomography in primary diagnosis, staging, and restaging of neuroendocrine tumor [J].

Kauhanen, Saila ;

Seppanen, Marko ;

Ovaska, Jari ;

Minn, Heikki ;

Bergman, Jorgen ;

Korsoff, Pirkko ;

Salmela, Pasi ;

Saltevo, Juha ;

Sane, Timo ;

Valimaki, Matti ;

Nuutila, Pirjo .

[6] Bilateral Symmetrical Adrenal Hypermetabolism on FDG PET in Paraneoplastic Cushing Syndrome in Breast Carcinoma Correlation With Contrast-Enhanced Computed Tomography [J].

Pruthi, Ankur ;

Basu, Sandip ;

Ramani, Subhash K. ;

Arya, Supreeta .

CLINICAL NUCLEAR MEDICINE, 2010, 35 (12) :960-961

[7]

Terada T, 2012, INT J CLIN EXP PATHO, V5, P159

[8] Association of hypertension and hypokalemia with Cushing's syndrome caused by ectopic ACTH secretion - A series of 58 cases [J].

Torpy, DJ ;

Mullen, N ;

Ilias, A ;

Nieman, LK .

ENDOCRINE HYPERTENSION, 2002, 970 :134-144

[9] Procedure guidelines for PET/CT tumour imaging with 68Ga-DOTA-conjugated peptides: 68Ga-DOTA-TOC, 68Ga-DOTA-NOC, 68Ga-DOTA-TATE [J].

Virgolini, Irene ;

Ambrosini, Valentina ;

Bomanji, Jamshed B. ;

Baum, Richard P. ;

Fanti, Stefano ;

Gabriel, Michael ;

Papathanasiou, Nikolaos D. ;

Pepe, Giovanna ;

Oyen, Wim ;

De Cristoforo, Clemens ;

Chiti, Arturo .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2010, 37 (10) :2004-2010

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