Dietary Crocin is Protective in Pancreatic Cancer while Reducing Radiation-Induced Hepatic Oxidative Damage

被引：45

作者：

Bakshi, Hamid A. ^{[1
]}

Al Zoubi, Mazhar S. ^{[2
]}

Faruck, Hakkim L. ^{[3
]}

Aljabali, Alaa A. A. ^{[4
]}

Rabi, Firas A. ^{[5
]}

Hafiz, Amin A. ^{[6
]}

Al-Batanyeh, Khalid M. ^{[7
]}

Al-Trad, Bahaa ^{[7
]}

Ansari, Prawej ^{[8
]}

Nasef, Mohamed M. ^{[9
]}

Charbe, Nitin B. ^{[10
]}

Satija, Saurabh ^{[11
,12
]}

Mehta, Meenu ^{[11
,12
]}

Mishra, Vijay ^{[11
]}

Gupta, Gaurav ^{[13
]}

Abobaker, Salem ^{[14
]}

Negi, Poonam ^{[15
]}

Azzouz, Ibrahim M. ^{[16
,17
]}

Dardouri, Ashref Ali K. ^{[18
]}

Dureja, Harish ^{[19
]}

Prasher, Parteek ^{[20
]}

Chellappan, Dinesh K. ^{[21
]}

Dua, Kamal ^{[12
,15
]}

Da Silva, Mateus Webba ^{[1
]}

El Tanani, Mohamed ^{[22
]}

McCarron, Paul A. ^{[1
]}

Tambuwala, Murtaza M. ^{[1
]}

机构：

[1] Ulster Univ, Sch Pharm & Pharmaceut Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[2] Yarmouk Univ, Fac Med, Dept Basic Med Sci, Irbid 566, Jordan

[3] Dhofar Univ, Coll Arts & Appl Sci, Dept Math & Sci, Salalah 211, Oman

[4] Yarmouk Univ, Fac Pharm, Dept Pharmaceut & Pharmaceut Technol, Irbid 566, Jordan

[5] Yarmouk Univ, Fac Med, Dept Clin Sci, Irbid 21163, Jordan

[6] Umm Qura Al Univ, Fac Appl Med Sci, Dept Clin Nutr, Mecca 21421, Saudi Arabia

[7] Yarmouk Univ, Fac Sci, Dept Biol Sci, Irbid 566, Jordan

[8] Ulster Univ, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[9] Univ Huddersfield, Sch Appl Sci, Dept Pharm & Biomed Sci, Huddersfield HD1 3DH, W Yorkshire, England

[10] Pontificia Univ Catolica Chile, Fac Quim & Farm, Dept Quim Organ, Av Libertador Bernardo OHiggins, Santiago 340, Chile

[11] Lovely Profess Univ, Sch Pharmaceut Sci, Phagwara 144411, Punjab, India

[12] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia

[13] Suresh Gyan Vihar Univ, Sch Pharm, Mahal Rd, Jaipur 302017, Rajasthan, India

[14] Klinikum Charite Univ Med Berlin, Dept Gynecol, European Competence Ctr Ovarian Canc, Campus Virchow,Augustenburger Pl 1, D-13353 Berlin, Germany

[15] Shoolini Univ, Sch Pharmaceut Sci, Solan 173229, Himachal Prades, India

[16] Charite Univ Med Berlin, Dept Dermatol Venerol & Allergol, Charitepl 1, D-10117 Berlin, Germany

[17] Free Univ Berlin, Charitepl 1, D-10117 Berlin, Germany

[18] Univ Huddersfield, Sch Appl Sci, Dept Forens Sci, Huddersfield HD1 3DH, W Yorkshire, England

[19] Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak 124001, Haryana, India

[20] Univ Petr & Energy Studies, Dept Chem, Dehra Dun 248007, Uttarakhand, India

[21] Int Med Univ, Sch Pharm, Dept Life Sci, Kuala Lumpur 57000, Malaysia

[22] Al Ahliyya Amman Univ, Fac Pharm, Pharmacol & Diagnost Res Ctr, Amman 19328, Jordan

来源：

NUTRIENTS | 2020年 / 12卷 / 06期

关键词：

pancreatic cancer; crocin; apoptosis; cell cycle; radiation; hepatic injury; INDUCED APOPTOSIS; KASHMIRI SAFFRON; SATIVUS L; IN-VITRO; CELLS; ACID; ACTIVATION; EXTRACT; PHOSPHORYLATION; INACTIVATION;

D O I：

10.3390/nu12061901

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although surgery and chemotherapy are standard treatment options, post-treatment outcomes often end in a poor prognosis. In the present study, we investigated anti-pancreatic cancer and amelioration of radiation-induced oxidative damage by crocin. Crocin is a carotenoid isolated from the dietary herb saffron, a prospect for novel leads as an anti-cancer agent. Crocin significantly reduced cell viability of BXPC3 and Capan-2 by triggering caspase signaling via the downregulation of Bcl-2. It modulated the expression of cell cycle signaling proteins P53, P21, P27, CDK2, c-MYC, Cyt-c and P38. Concomitantly, crocin treatment-induced apoptosis by inducing the release of cytochrome c from mitochondria to cytosol. Microarray analysis of the expression signature of genes induced by crocin showed a substantial number of genes involved in cell signaling pathways and checkpoints (723) are significantly affected by crocin. In mice bearing pancreatic tumors, crocin significantly reduced tumor burden without a change in body weight. Additionally, it showed significant protection against radiation-induced hepatic oxidative damage, reduced the levels of hepatic toxicity and preserved liver morphology. These findings indicate that crocin has a potential role in the treatment, prevention and management of pancreatic cancer.

引用

页码：1 / 19

页数：18

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