miRNAs, polyphenols, and chronic disease

被引：51

作者：

Blade, Cinta ^{[1
]}

Baselga-Escudero, Laura ^{[1
]}

Josepa Salvado, Maria ^{[1
]}

Arola-Arnal, Anna ^{[1
]}

机构：

[1] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Tarragona 43007, Spain

来源：

MOLECULAR NUTRITION & FOOD RESEARCH | 2013年 / 57卷 / 01期

关键词：

Cardiovascular; Insulin; Lipid metabolism; MicroRNA; Polyphenols; MICRORNA EXPRESSION PROFILES; INFLAMMATORY GENE-EXPRESSION; CIRCULATING MICRORNAS; CHOLESTEROL EFFLUX; CARDIAC-HYPERTROPHY; TARGET RECOGNITION; INSULIN-RESISTANCE; LIPID-METABOLISM; MESSENGER-RNAS; NITRIC-OXIDE;

D O I：

10.1002/mnfr.201200454

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

MicroRNAs (miRNAs) are small noncoding RNAs, approximately 1825 nucleotides in length, that modulate gene expression at the posttranscriptional level. Thousands of miRNAs have been described, and it is thought that they regulate some aspects of more than 60% of all human cell transcripts. Several polyphenols have been shown to modulate miRNAs related to metabolic homeostasis and chronic diseases. Polyphenolic modulation of miRNAs is very attractive as a strategy to target numerous cell processes and potentially reduce the risk of chronic disease. Evidence is building that polyphenols can target specific miRNAs, such as miR-122, but more studies are necessary to discover and validate additional miRNA targets.

引用

页码：58 / 70

页数：13

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