共 138 条
The Francisella tularensis proteome and its recognition by antibodies
被引:17
作者:

Kilmury, Sara L. N.
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机构:
Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada

Twine, Susan M.
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h-index: 0
机构:
Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada
机构:
[1] Natl Res Council Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada
来源:
FRONTIERS IN MICROBIOLOGY
|
2011年
/
2卷
关键词:
Francisella tularensis;
LVS;
immunoproteomics;
proteome microarray;
2D-PAGE;
antibody;
vaccine;
mouse vaccination;
LIVE VACCINE STRAIN;
CELL-MEDIATED-IMMUNITY;
OUTER-MEMBRANE PROTEIN;
INTRACELLULAR BACTERIAL PATHOGEN;
PROTECTIVE IMMUNITY;
HUMORAL IMMUNITY;
IMMUNOREACTIVE ANTIGENS;
PULMONARY CHALLENGE;
HELICOBACTER-PYLORI;
VIRULENT-STRAINS;
D O I:
10.3389/fmicb.2010.00143
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
Francisella tularensis is the causative agent of a spectrum of diseases collectively known as tularemia. The extreme virulence of the pathogen in humans, combined with the low infectious dose and the ease of dissemination by aerosol have led to concerns about its abuse as a bioweapon. Until recently, nothing was known about the virulence mechanisms and even now, there is still a relatively poor understanding of pathogen virulence. Completion of increasing numbers of Francisella genome sequences, combined with comparative genomics and proteomics studies, are contributing to the knowledge in this area. Tularemia may be treated with antibiotics, but there is currently no licensed vaccine. An attenuated strain, the Live Vaccine Strain (LVS) has been used to vaccinate military and at risk laboratory personnel, but safety concerns mean that it is unlikely to be licensed by the FDA for general use. Little is known about the protective immunity induced by vaccination with LVS, in humans or animal models. Immunoproteomics studies with sera from infected humans or vaccinated mouse strains, are being used in gel-based or proteome microarray approaches to give insight into the humoral immune response. In addition, these data have the potential to be exploited in the identification of new diagnostic or protective antigens, the design of next generation live vaccine strains, and the development of subunit vaccines. Herein, we briefly review the current knowledge from Francisella comparative proteomics studies and then focus upon the findings from immunoproteomics approaches.
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共 138 条
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Engels, Reinhard
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MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA

Pearson, Matthew
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h-index: 0
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MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA

Howarth, Clint
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Larson, Lisa
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White, Jared
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Sjoestedt, Anders
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Umea Univ, Dept Clin Bacteriol, Umea, Sweden MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA

Titball, Richard
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Michell, Stephen L.
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Univ Exeter, Sch Biosci, Exeter, Devon, England MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA

Birren, Bruce
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h-index: 0
机构:
MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA MIT & Harvard, Microbial Anal Grp, Cambridge, MA 02139 USA

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