Gene-environment interactions of novel variants associated with head and neck cancer

被引：22

作者：

Liang, Caihua ^{[1
]}

Marsit, Carmen J. ^{[1
,2
]}

Houseman, E. Andres ^{[1
]}

Butler, Rondi ^{[2
]}

Nelson, Heather H. ^{[3
]}

McClean, Michael D. ^{[4
]}

Kelsey, Karl T. ^{[1
,2
]}

机构：

[1] Brown Univ, Dept Community Hlth, Providence, RI 02912 USA

[2] Brown Univ, Dept Pathol & Lab Med, Div Biol & Med, Providence, RI 02912 USA

[3] Univ Minnesota, Div Epidemiol & Community Hlth, Mason Canc Ctr, Minneapolis, MN USA

[4] Boston Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2012年 / 34卷 / 08期

关键词：

post-genome-wide association study; head and neck cancer; gene and environment interaction; SQUAMOUS-CELL CARCINOMA; GENOME-WIDE ASSOCIATION; HEPATOCELLULAR-CARCINOMA; ALCOHOL-DEHYDROGENASE; POOLED ANALYSIS; RISK; TOBACCO; POLYMORPHISMS; PHARYNGEAL; EPIDEMIOLOGY;

D O I：

10.1002/hed.21867

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background A genome-wide association study for upper aerodigestive tract cancers identified 19 candidate single-nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential genegene and geneenvironment interactions in head and neck squamous cell carcinoma (HNSCC) risk. Methods The 19 variants were genotyped using Taqman assays among 575 cases and 676 controls in our population-based casecontrol study. Results A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC. Classification and regression tree analysis demonstrated a higher-order interaction between smoking status, ADH1B, FLJ13089, and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84). Conclusions Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups. (c) 2011 Wiley Periodicals, Inc. Head Neck, 2012

引用

页码：1111 / 1118

页数：8

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