Electrospray ionization tandem mass spectrometric characteristics and fragmentation mechanisms of distamycin analogues

被引:11
作者
Tang, FL
Wang, J
Liu, D
Yuan, G [1 ]
Liu, Y
Zhu, CJ
Zhao, YF
机构
[1] Peking Univ, Coll Chem, Minist Educ, Key Lab Bioorgan Chem & Mol Engn,Dept Chem Biol, Beijing 100871, Peoples R China
[2] Tsing Hua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem, Beijing 100084, Peoples R China
关键词
D O I
10.1002/rcm.680
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The electrospray ionization tandem mass spectrometric (ESI-MS/MS) characteristics and fragmentation mechanisms of eight distamycin analogues containing N-methylpyrrole and N-methylimidazole were investigated. The members of two isomeric groups of distamycin analogues with the same elemental composition can be distinguished by MS/MS spectra of protonated molecules and of significant fragment ions. Copyright (C) 2002 John Wiley Sons, Ltd.
引用
收藏
页码:1035 / 1039
页数:5
相关论文
共 4 条
[1]   CHEMISTRY OF PHOSPHODIESTERS, DNA AND MODELS .7. MICROGONOTROPENS AND THEIR INTERACTIONS WITH DNA .5. STRUCTURAL CHARACTERIZATION OF THE 1-1-COMPLEX OF D(CGCAAATTTGCG)(2) AND TREN-MICROGONOTROPEN-B BY 2D NMR-SPECTROSCOPY AND RESTRAINED MOLECULAR MODELING [J].
BLASKO, A ;
BROWNE, KA ;
BRUICE, TC .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1994, 116 (09) :3726-3737
[2]   Electrospray tandem mass spectrometry of lexitropsins [J].
Domingues, MRM ;
Domingues, P ;
Gajewski, M ;
Czuchajowski, L ;
Ferrer-Correia, AJ .
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2001, 15 (12) :908-914
[3]   Regulation of gene expression by small molecules [J].
Gottesfeld, JM ;
Neely, L ;
Trauger, JW ;
Baird, EE ;
Dervan, PB .
NATURE, 1997, 387 (6629) :202-205
[4]   A convenient method for the synthesis of DNA-recognizing polyamides in solution [J].
Xiao, JH ;
Yuan, G ;
Huang, WQ ;
Chan, ASC ;
Lee, KLD .
JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (18) :5506-5513