Analysis of cerebral toxoplasmosis in a series of 170 allogeneic hematopoietic stem cell transplant patients

被引：46
作者：
Hakko, E. [1 ]
Ozkan, H. A. [1 ]
Karaman, K. [1 ]
Gulbas, Z. [1 ]
机构：
[1] Anadolu Med Ctr, TR-41400 Gebze, Kocaeli, Turkey
来源：
TRANSPLANT INFECTIOUS DISEASE | 2013年 / 15卷 / 06期
关键词：
cerebral toxoplasmosis; allogeneic transplantation; cranial MRI; PCR; treatment; prophylaxis; Toxoplasma gondii; BONE-MARROW-TRANSPLANTATION; GONDII INFECTION; RECIPIENTS; DIAGNOSIS; SEROPOSITIVITY; ENCEPHALITIS; PREVENTION; EXPERIENCE; PROVINCE; BLOOD;
D O I：
10.1111/tid.12138
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IntroductionCerebral toxoplasmosis is a rare but fatal complication in hematopoietic stem cell transplant patients, which mostly is caused by reactivation of latent disease. MethodsIn this study, we report an analysis of cerebral toxoplasmosis in a series of 170 allogeneic stem cell transplant patients during a 30-month period at our institution. ResultsAmong these allogeneic stem cell transplant patients, 5 were diagnosed with cerebral toxoplasmosis by brain magnetic resonance imaging and polymerase chain reaction of Toxoplasma gondii DNA. The incidence of cerebral toxoplasmosis was found to be 2.94%. ConclusionMortality rate is known to be very high in cerebral toxoplasmosis; therefore, it is life saving to diagnose the disease in the early stages and start treatment promptly, especially in high-endemic countries like Turkey.
引用
收藏
页码：575 / 580
页数：6
相关论文
共 29 条
[21]   Laboratory diagnosis of Toxoplasma gondii infection with direct and indirect diagnostic techniques [J].
Pignanelli, Salvatore .
INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2011, 54 (04) :786-789
[22]   Comparison of high and low doses of trimethoprim-sulfamethoxazole for primary prevention of toxoplasmic encephalitis in human immunodeficiency virus-infected patients [J].
Ribera, E ;
Fernandez-Sola, A ;
Juste, C ;
Rovira, A ;
Romero, FJ ;
Armadans-Gil, L ;
Ruiz, I ;
Ocaña, I ;
Pahissa, A .
CLINICAL INFECTIOUS DISEASES, 1999, 29 (06) :1461-1466
[23]   Toxoplasmosis, a severe complication in allogeneic hematopoietic stem cell transplantation:: Successful treatment strategies during a 5-year single-center experience [J].
Roemer, E ;
Blau, IW ;
Basara, N ;
Kiehl, MG ;
Bischoff, M ;
Günzelmann, S ;
Kirsten, D ;
Sanchez, H ;
Wocker, EL ;
Fauser, AA .
CLINICAL INFECTIOUS DISEASES, 2001, 32 (01) :E1-E8
[24]  
Sensini Alessandra, 1996, Clin Microbiol Infect, V2, P25, DOI 10.1111/j.1469-0691.1996.tb00196.x
[25]   Pulmonary toxoplasmosis in bone marrow transplant recipients: Report of two cases and review [J].
Sing, A ;
Leitritz, L ;
Roggenkamp, A ;
Kolb, HJ ;
Szabados, A ;
Fingerle, V ;
Autenrieth, IB ;
Heesemann, J .
CLINICAL INFECTIOUS DISEASES, 1999, 29 (02) :429-433
[26]  
SLAVIN MA, 1994, BONE MARROW TRANSPL, V13, P549
[27]  
Tamer GS, 2009, CLIN INVEST MED, V32, pE43
[28]  
Tekay Fikret, 2007, Turkiye Parazitoloji Dergisi, V31, P176
[29]   Cerebral toxoplasmosis - a late complication of allogeneic haematopoietic stem cell transplantation [J].
Zver, S ;
Cernelc, P ;
Mlakar, U ;
Pretnar, J .
BONE MARROW TRANSPLANTATION, 1999, 24 (12) :1363-1365
123