Analysis of cerebral toxoplasmosis in a series of 170 allogeneic hematopoietic stem cell transplant patients

被引：46
作者：
Hakko, E. [1 ]
Ozkan, H. A. [1 ]
Karaman, K. [1 ]
Gulbas, Z. [1 ]
机构：
[1] Anadolu Med Ctr, TR-41400 Gebze, Kocaeli, Turkey
来源：
TRANSPLANT INFECTIOUS DISEASE | 2013年 / 15卷 / 06期
关键词：
cerebral toxoplasmosis; allogeneic transplantation; cranial MRI; PCR; treatment; prophylaxis; Toxoplasma gondii; BONE-MARROW-TRANSPLANTATION; GONDII INFECTION; RECIPIENTS; DIAGNOSIS; SEROPOSITIVITY; ENCEPHALITIS; PREVENTION; EXPERIENCE; PROVINCE; BLOOD;
D O I：
10.1111/tid.12138
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IntroductionCerebral toxoplasmosis is a rare but fatal complication in hematopoietic stem cell transplant patients, which mostly is caused by reactivation of latent disease. MethodsIn this study, we report an analysis of cerebral toxoplasmosis in a series of 170 allogeneic stem cell transplant patients during a 30-month period at our institution. ResultsAmong these allogeneic stem cell transplant patients, 5 were diagnosed with cerebral toxoplasmosis by brain magnetic resonance imaging and polymerase chain reaction of Toxoplasma gondii DNA. The incidence of cerebral toxoplasmosis was found to be 2.94%. ConclusionMortality rate is known to be very high in cerebral toxoplasmosis; therefore, it is life saving to diagnose the disease in the early stages and start treatment promptly, especially in high-endemic countries like Turkey.
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收藏
页码：575 / 580
页数：6
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