The role of Fluorine-18-Fluorodeoxyglucose positron emission tomography in staging and restaging of patients with osteosarcoma

被引：48

作者：

Quartuccio, Natale ^{[1
]}

Treglia, Giorgio ^{[2
,3
]}

Salsano, Marco ^{[4
]}

Mattoli, Maria Vittoria ^{[5
]}

Muoio, Barbara ^{[6
]}

Piccardo, Arnoldo ^{[7
]}

Lopci, Egesta ^{[8
]}

Cistaro, Angelina ^{[9
]}

机构：

[1] Univ Messina, Dept Radiol Sci, Nucl Med Unit, Messina, Italy

[2] Oncol Inst Southern Switzerland, Dept Nucl Med, Bellinzona, Switzerland

[3] Oncol Inst Southern Switzerland, PET CT Ctr, Bellinzona, Switzerland

[4] Univ Cattolica Sacro Cuore, Inst Radiol, I-00168 Rome, Italy

[5] Univ Cattolica Sacro Cuore, Inst Nucl Med, I-00168 Rome, Italy

[6] Univ Cattolica Sacro Cuore, Sch Med, I-00168 Rome, Italy

[7] Galliera Hosp, Nucl Med Unit, Genoa, Italy

[8] Humanitas Hosp, Nucl Med Unit, Milan, Italy

[9] Euromedic Inc, Positron Emiss Tomog Ctr IRMET, Turin, Italy

来源：

RADIOLOGY AND ONCOLOGY | 2013年 / 47卷 / 02期

关键词：

osteosarcoma; bone sarcoma; F-18-Fluorodeoxyglucose; PET/CT; positron emission tomography; HIGH-GRADE OSTEOSARCOMA; STUDY-GROUP PROTOCOLS; PRIMARY BONE-TUMORS; FDG-PET; PULMONARY METASTASES; F-18-FDG PET/CT; SARCOMA; CHEMOTHERAPY; EXTREMITIES; EXPERIENCE;

D O I：

10.2478/raon-2013-0017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. The objective of this study is to systematically review the role of positron emission tomography (PET) and PET/computed tomography (PET/CT) with Fluorine-18-Fluorodeoxyglucose (FDG) in patients with osteosarcoma (OS). Methods. A comprehensive literature search of published studies through October 10,h, 2012 in PubMed/MEDLINE, Embase and Scopus databases regarding whole-body FDG-PET and FDG-PET/CT in patients with OS was performed. Results. We identified 13 studies including 289 patients with OS. With regard to the staging and restaging of OS, the diagnostic performance of FDG-PET and PET/CT seem to be high; FDG-PET and PET/CT seem to be superior to bone scintigraphy and conventional imaging methods in detecting bone metastases; conversely, spiral CT seems to be superior to FDG-PET in detecting pulmonary metastases from OS Conclusions. Metabolic imaging may provide additional information in the evaluation of OS patients. The combination of FDG-PET or FDG-PET/CT with conventional imaging methods seems to be a valuable tool in the staging and restaging of OS and may have a relevant impact on the treatment planning.

引用

页码：97 / 102

页数：6

共 31 条

[1] Medical Progress - Common musculoskeletal tumors of childhood and adolescence [J].

Arndt, CAS ;

Crist, WM .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (05) :342-352

[2] High Grade Osteosarcoma of the Extremities With Lung Metastases at Presentation: Treatment With Neoadjuvant Chemotherapy and Simultaneous Resection of Primary and Metastatic Lesions [J].

Bacci, Gaetano ;

Rocca, Michele ;

Salone, Mariacristina ;

Balladelli, Alba ;

Ferrari, Stefano ;

Palmerini, Emanuela ;

Forni, Cristiana ;

Briccoli, Antonio .

JOURNAL OF SURGICAL ONCOLOGY, 2008, 98 (06) :415-420

[3]

Bandopadhyaya G P, 2012, ISRN Oncol, V2012, P371830, DOI 10.5402/2012/371830

[4] Prognostic factors in high-grade osteosarcoma of the extremities or trunk:: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols [J].

Bielack, SS ;

Kempf-Bielack, B ;

Delling, G ;

Exner, GU ;

Flege, S ;

Helmke, K ;

Kotz, R ;

Salzer-Kuntschik, M ;

Werner, M ;

Winkelmann, W ;

Zoubek, A ;

Jürgens, H ;

Winkler, K .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (03) :776-790

[5] Osteosarcoma: The COSS Experience [J].

Bielack, Stefan ;

Juergens, Herbert ;

Jundt, Gernot ;

Kevric, Matthias ;

Kuehne, Thomas ;

Reichardt, Peter ;

Zoubek, Andreas ;

Werner, Mathias ;

Winkelmann, Winfried ;

Kotz, Rainer .

PEDIATRIC AND ADOLESCENT OSTEOSARCOMA, 2009, 152 :289-+

[6] Bone Tumors in Adolescents and Young Adults [J].

Bielack, Stefan S. ;

Carrle, Dorothe ;

Hardes, Jendrik ;

Schuck, Andreas ;

Paulussen, Michael .

CURRENT TREATMENT OPTIONS IN ONCOLOGY, 2008, 9 (01) :67-80

[7] FDG PET/CT imaging in primary osseous and soft tissue sarcomas: a retrospective review of 212 cases [J].

Charest, Mathieu ;

Hickeson, Marc ;

Lisbona, Robert ;

Novales-Diaz, Javier-A. ;

Derbekyan, Vilma ;

Turcotte, Robert E. .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2009, 36 (12) :1944-1951

[8] Imaging primary prostate cancer with 11C-Choline PET/CT: relation to tumour stage, Gleason score and biomarkers of biologic aggressiveness [J].

Chen, Ji ;

Zhao, Yong ;

Li, Xin ;

Sun, Peng ;

Wang, Muwen ;

Wang, Ridong ;

Jin, Xunbo .

RADIOLOGY AND ONCOLOGY, 2012, 46 (03) :179-188

[9] The role of 18F-FDG PET/CT in the metabolic characterization of lung nodules in pediatric patients with bone sarcoma [J].

Cistaro, Angela ;

Lopci, Egesta ;

Gastaldo, Luca ;

Fania, Piercarlo ;

del Prever, Adalberto Brach ;

Fagioli, Franca .

PEDIATRIC BLOOD & CANCER, 2012, 59 (07) :1206-1210

[10] FDG-PET for detection of pulmonary metastases from malignant primary bone tumors:: Comparison with spiral CT [J].

Franzius, C ;

Daldrup-Link, HE ;

Sciuk, J ;

Rummeny, EJ ;

Bielack, S ;

Jürgens, H ;

Schober, O .

ANNALS OF ONCOLOGY, 2001, 12 (04) :479-486

← 1 2 3 4 →