Effects of permethrin on muscarinic cholinergic receptors in mouse striatum

被引：0

作者：

Prutipanlai, S ^{[1
]}

Chongthammakun, S ^{[1
]}

Piyachaturawat, P ^{[1
]}

Wongsawatkul, O ^{[1
]}

Watcharasit, P ^{[1
]}

Satayavivad, J ^{[1
]}

机构：

[1] Mahidol Univ, Fac Sci, Toxicol Grad Programme, Bangkok 10400, Thailand

来源：

New Trends in Alzheimer and Parkinson Related Disorders: ADPD 2005 | 2005年

关键词：

SUBTYPES; MICE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of permethrin (PM), a type I pyrethroid, on the cholinergic controlling motor activity in the striatum were studied in orally PM- treated mice, once daily for up to 14 days. The results showed that PM significantly decreased ambulatory activities in dose related manner and caused the alterations in acetylcholinesterase (AChE) activity and the expression of the muscarinic acetylcholine receptor (mAChR). The relationships between the changes in mAChR expression and pathogenesis of Parkinson's disease caused by PM should be further investigated.

引用

页码：131 / 136

页数：6

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