Commercial porcine circovirus type 2 vaccines: Efficacy and clinical application

被引：110

作者：

Chae, Chanhee ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Vet Med, Dept Vet Pathol, Seoul 151742, South Korea

来源：

VETERINARY JOURNAL | 2012年 / 194卷 / 02期

关键词：

Porcine circovirus type 2; Postweaning multisystemic wasting syndrome; Porcine circovirus-associated disease; Vaccine; MULTISYSTEMIC WASTING SYNDROME; EXPERIMENTALLY-INFECTED BOARS; RESPIRATORY SYNDROME VIRUS; REAL-TIME PCR; SYNDROME PMWS; PCV2; VACCINATION; ARTIFICIAL-INSEMINATION; INDUCED IMMUNITY; AFFECTED PIGS; SEMEN;

D O I：

10.1016/j.tvjl.2012.06.031

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Porcine circovirus type 2 (PCV2) is the one of the most economically important pathogens of pigs. After postweaning multisystemic wasting syndrome (PMWS) was first identified and reported in western Canada in 1991, it took 13 years for the first commercial PCV2 vaccine to be used under special licence in France and Germany in 2004. Along with PMWS, PCV2 is also associated with a number of diseases and syndromes, collectively referred to as porcine circovirus-associated disease (PCVAD). Currently, five commercial vaccines are available on the international market. Commercial PCV2 vaccines were initially developed to control PMWS, but they are now also used against other PCVAD. This review focuses on (1) the types of commercial vaccines; (2) the criteria of vaccine efficacy; (3) the clinical, virological, immunological and pathological efficacy of the vaccines; and (4) the use of PCV2 vaccines against different clinical manifestations of PCVAD. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：151 / 157

页数：7

共 63 条

[11]

Clark T., 1996, 1 P W CAN ASS SWIN P, P22

[12]

Cline G, 2008, VET REC, V163, P737

[13] Immunology of porcine circovirus type 2 (PCV2) [J].

Darwich, Laila ;

Mateu, Enric .

VIRUS RESEARCH, 2012, 164 (1-2) :61-67

[14] The effect of vaccination against porcine circovirus type 2 in pigs suffering from porcine respiratory disease complex [J].

Fachinger, Vicky ;

Bischoff, Ralf ;

Ben Jedidia, Samir ;

Saalmueller, Armin ;

Elbers, Knut .

VACCINE, 2008, 26 (11) :1488-1499

[15] A chimeric porcine circovirus (PCV) with the immunogenic capsid gene of the pathogenic PCV type 2 (PCV2) cloned into the genomic backbone of the nonpathogenic PCV1 induces protective immunity against PCV2 infection in pigs [J].

Fenaux, M ;

Opriessnig, T ;

Halbur, PG ;

Elvinger, F ;

Meng, XJ .

JOURNAL OF VIROLOGY, 2004, 78 (12) :6297-6303

[16] Porcine circovirus type 2 (PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins [J].

Fort, M. ;

Sibila, M. ;

Allepuz, A. ;

Mateu, E. ;

Roerink, F. ;

Segales, J. .

VACCINE, 2008, 26 (08) :1063-1071

[17] One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model [J].

Fort, M. ;

Sibila, M. ;

Perez-Martin, E. ;

Nofrarias, M. ;

Mateu, E. ;

Segales, J. .

VACCINE, 2009, 27 (30) :4031-4037

[18] Detection of neutralizing antibodies in postweaning multisystemic wasting syndrome (PMWS)-affected and non-PMWS-affected pigs [J].

Fort, Maria ;

Olvera, Alex ;

Sibila, Marina ;

Segales, Joaquim ;

Mateu, Enric .

VETERINARY MICROBIOLOGY, 2007, 125 (3-4) :244-255

[19] Development of cell-mediated immunity to porcine circovirus type 2 (PCV2) in caesarean-derived, colostrum-deprived piglets [J].

Fort, Maria ;

Fernandes, Lana T. ;

Nofrarias, Miquel ;

Diaz, Ivan ;

Sibila, Marina ;

Pujols, Joan ;

Mateu, Enric ;

Segales, Joaquim .

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2009, 129 (1-2) :101-107

[20] Inactivated PCV2 one shot vaccine applied in 3-week-old piglets: Improvement of production parameters and interaction with maternally derived immunity [J].

Fraile, Lorenzo ;

Grau-Roma, Llorenc ;

Sarasola, Patxi ;

Sinovas, Nuria ;

Nofrarias, Miquel ;

Lopez-Jimenez, Rosa ;

Lopez-Soria, Sergio ;

Sibila, Marina ;

Segales, Joaquim .

VACCINE, 2012, 30 (11) :1986-1992

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