Supported hybrid bilayer membranes as rugged cell membrane mimics

被引：301

作者：

Plant, AL ^{[1
]}

机构：

[1] Natl Inst Stand & Technol, Div Biotechnol, Gaithersburg, MD 20899 USA

来源：

LANGMUIR | 1999年 / 15卷 / 15期

关键词：

D O I：

10.1021/la981662t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Supported planar lipid bilayers based on alkanethiol-tethering chemistry are becoming increasingly important biomimetic materials. Hybrid bilayers containing thiol-derivatized alkane moieties plus natural Lipids provide a biomimetic matrix that permits the successful reconstitution of membrane protein activity. The hybrid membrane is self-assembled and sufficiently rugged to be of practical use in research and in commercial sensing applications. The coupling of the bilayer to a metal support allows a wide range of analytical techniques to be applied to this model membrane. This article reviews some of the fundamental studies of the formation, structure, and response of hybrid bilayer membranes.

引用

页码：5128 / 5135

页数：8

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