CORTICAL EXCITABILITY AND REFRACTORY EPILEPSY: A THREE-YEAR LONGITUDINAL TRANSCRANIAL MAGNETIC STIMULATION STUDY

被引：61
作者：
Badawy, Radwa A. B. [1 ]
Jackson, Graeme D.
Berkovic, Samuel F.
Macdonell, Richard A. L.
机构：
[1] Austin Hlth, Dept Neurol, Heidelberg, Vic, Australia
来源：
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS | 2013年 / 23卷 / 01期
关键词：
Cortical excitability; refractory epilepsy; seizures; seizure freedom; transcranial magnetic stimulation; TEMPORAL-LOBE EPILEPSY; JUVENILE MYOCLONIC EPILEPSY; MOTOR CORTEX EXCITABILITY; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HIPPOCAMPAL DAMAGE; SLEEP-DEPRIVATION; SEIZURES; TMS; INHIBITION;
D O I：
10.1142/S012906571250030X
中图分类号：
TP18 [人工智能理论];
学科分类号：
081104 ; 0812 ; 0835 ; 1405 ;
摘要：
Transcranial magnetic stimulation was used to study the effect of recurrent seizures on cortical excitability over time in epilepsy. 77 patients with firm diagnoses of idiopathic generalized epilepsy (IGE) or focal epilepsy were repeatedly evaluated over three years. At onset, all groups had increased cortical excitability. At the end of follow-up the refractory group was associated with a broad increase in cortical excitability. Conversely, cortical excitability decreased in all seizure free groups after introduction of an effective medication.
引用
收藏
页数：18
相关论文
共 60 条
  • [1] Cortical excitability in juvenile myoclonic epileptic patients and their asymptomatic siblings: A transcranial magnetic stimulation study
    Akgun, Yasemin
    Soysal, Aysun
    Atakli, Dilek
    Yuksel, Burcu
    Dayan, Cengiz
    Arpaci, Baki
    [J]. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2009, 18 (06): : 387 - 391
  • [2] Sleep deprivation increases cortical excitability in epilepsy - Syndrome-specific effects
    Badawy, R. A. B.
    Curatolo, J. M.
    Newton, M.
    Berkovic, S. F.
    Macdonell, R. A. L.
    [J]. NEUROLOGY, 2006, 67 (06) : 1018 - 1022
  • [3] Why do seizures in generalized epilepsy often occur in the morning?
    Badawy, R. A. B.
    Macdonell, R. A. L.
    Jackson, G. D.
    Berkovic, S. F.
    [J]. NEUROLOGY, 2009, 73 (03) : 218 - 222
  • [4] The peri-ictal state: cortical excitability changes within 24 h of a seizure
    Badawy, Radwa
    Macdonell, Richard
    Jackson, Graeme
    Berkovic, Samuel
    [J]. BRAIN, 2009, 132 : 1013 - 1021
  • [5] Changes in cortical excitability differentiate generalized and focal epilepsy
    Badawy, Radwa A. B.
    Curatolo, Josie M.
    Newton, Mark
    Berkovic, Samuel F.
    Macdonell, Richard A. L.
    [J]. ANNALS OF NEUROLOGY, 2007, 61 (04) : 324 - 331
  • [6] Can changes in cortical excitability distinguish progressive from juvenile myoclonic epilepsy?
    Badawy, Radwa A. B.
    Macdonell, Richard A. L.
    Jackson, Graeme D.
    Berkovic, Samuel F.
    [J]. EPILEPSIA, 2010, 51 (10) : 2084 - 2088
  • [7] Predicting Seizure Control: Cortical Excitability and Antiepileptic Medication
    Badawy, Radwa A. B.
    Macdonell, Richard A. L.
    Berkovic, Samuel F.
    Newton, Mark R.
    Jackson, Graeme D.
    [J]. ANNALS OF NEUROLOGY, 2010, 67 (01) : 64 - 73
  • [8] Do seizures beget seizures? An assessment of the clinical evidence in humans
    Berg, AT
    Shinnar, S
    [J]. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1997, 14 (02) : 102 - 110
  • [9] Human epilepsies: interaction of genetic and acquired factors
    Berkovic, Samuel F.
    Mulley, John C.
    Scheffer, Ingrid E.
    Petrou, Steven
    [J]. TRENDS IN NEUROSCIENCES, 2006, 29 (07) : 391 - 397
  • [10] Longitudinal and cross-sectional analysis of atrophy in pharmacoresistant temporal lobe epilepsy
    Bernhardt, B. C.
    Worsley, K. J.
    Kim, H.
    Evans, A. C.
    Bernasconi, A.
    Bernasconi, N.
    [J]. NEUROLOGY, 2009, 72 (20) : 1747 - 1754
123456