A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats

被引：13

作者：

Molinar-Toribio, Eunice ^{[1
,6
]}

Fuguet, Elisabet ^{[2
,3
]}

Ramos-Romero, Sara ^{[1
]}

Taltavull, Noria ^{[4
]}

Mendez, Lucia ^{[5
]}

Rosa Nogues, M. ^{[4
]}

Medina, Isabel ^{[5
]}

Lluis Torres, Josep ^{[1
]}

Perez-Jimenez, Jara ^{[1
,7
]}

机构：

[1] Inst Adv Chem Catalonia IQAC CSIC, Barcelona, Spain

[2] Univ Barcelona, Dept Quim Analit, Barcelona, Spain

[3] Generalitat Catalunya, Serra Hunter Programme, Barcelona, Spain

[4] Univ Rovira & Virgili, Unidad Farmacol, Fac Med & Ciencias Salud, Reus, Spain

[5] Inst Invest Marinas IIM CSIC, Vigo, Spain

[6] Univ Panama, Fac Nat Exact Sci & Technol, Dept Biochem, Panama City, Panama

[7] Inst Food Sci Technol & Nutr ICTAN CSIC, Dept Metab & Nutr, Jose Antonio Novais 10, Madrid 28040, Spain

来源：

EUROPEAN JOURNAL OF NUTRITION | 2018年 / 57卷 / 01期

关键词：

Polyphenols; Proanthocyanidins; High-fat high-sucrose diet; Bioavailability; Metabolites; GUT MICROBIOTA; INDUCED OBESITY; BIOAVAILABILITY; POLYPHENOLS; COCOA; ACID; TEA; IDENTIFICATION; INFLAMMATION; EXCRETION;

D O I：

10.1007/s00394-016-1323-9

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Purpose Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). Methods Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. Results A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. Conclusions These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes.

引用

页码：339 / 349

页数：11

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