Graphite catalyzed green synthesis of quinoxalines

被引：63

作者：

Kadam, Hari K. ^{[1
]}

Khan, Salman ^{[1
]}

Kunkalkar, Rupesh A. ^{[1
]}

Tilve, Santosh G. ^{[1
]}

机构：

[1] Goa Univ, Dept Chem, Taleigao Plateau 403206, Goa, India

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 08期

关键词：

Graphite; Green chemistry; Quinoxalines; SOLVENT-FREE CONDITIONS; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; ROOM-TEMPERATURE; ALPHA-HYDROXYKETONES; REUSABLE CATALYST; FACILE SYNTHESIS; RAPID SYNTHESIS; AQUEOUS-MEDIA; DERIVATIVES;

D O I：

10.1016/j.tetlet.2012.12.041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new simple approach using environmentally benign, cheap, and easily recyclable graphite as a heterogeneous catalyst for the synthesis of quinoxalines is described. A library of pharmacologically interesting diphenylquinoxalines is prepared by the double condensation of substituted benzils, phenanthrene-9,10-dione, and benzoin with aromatic diamines in 71-93% yields at room temperature in ethanol. Aliphatic diamines gave corresponding dihydropyrazines from substituted benzils in 72-92% yields. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1003 / 1007

页数：5

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