Exotic mitotic mechanisms

被引：41
作者：
Drechsler, Hauke [1 ]
McAinsh, Andrew D. [1 ]
机构：
[1] Univ Warwick, Warwick Med Sch, Div Biomed Cell Biol, Ctr Mechanochem Cell Biol, Coventry CV4 7AL, W Midlands, England
来源：
OPEN BIOLOGY | 2012年 / 2卷
基金：
英国生物技术与生命科学研究理事会;
关键词：
kinetochore; nuclear pore complex; mitosis; spindle; chromosome; NUCLEAR-PORE COMPLEX; SPINDLE POLE BODY; BUDDING YEAST KINETOCHORE; CELL-CYCLE; NUP107-160; COMPLEX; TRYPANOSOMA-BRUCEI; FINE-STRUCTURE; BASAL BODIES; CENP-E; MITOSIS;
D O I：
10.1098/rsob.120140
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The emergence of eukaryotes around two billion years ago provided new challenges for the chromosome segregation machineries: the physical separation of multiple large and linear chromosomes from the microtubule-organizing centres by the nuclear envelope. In this review, we set out the diverse solutions that eukaryotic cells use to solve this problem, and show how stepping away from 'mainstream' mitosis can teach us much about the mechanisms and mechanics that can drive chromosome segregation. We discuss the evidence for a close functional and physical relationship between membranes, nuclear pores and kinetochores in generating the forces necessary for chromosome segregation during mitosis.
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页数：11
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