Interplay Between Toxoplasma gondii, Autophagy, and Autophagy Proteins

被引：18

作者：

Subauste, Carlos S. ^{[1
,2
]}

机构：

[1] Case Western Reserve Univ, Dept Med, Div Infect Dis & HIV Med, Cleveland, OH 44106 USA

[2] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2019年 / 9卷

关键词：

autophagy; parasite; CD40; IFN-gamma; cell signaling; TRANSMEMBRANE MICRONEME PROTEINS; PATHOGEN-CONTAINING VACUOLES; IFN-GAMMA; REGULATE AUTOPHAGY; ANTIMICROBIAL ACTIVITY; DIRECT PHOSPHORYLATION; CONJUGATION SYSTEM; LIGAND INTERACTION; PSEUDOKINASE ROP5; MOUSE MACROPHAGES;

D O I：

10.3389/fcimb.2019.00139

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Survival of Toxoplasma gondii within host cells depends on its ability of reside in a vacuole that avoids lysosomal degradation and enables parasite replication. The interplay between immune-mediated responses that lead to either autophagy-driven lysosomal degradation or disruption of the vacuole and the strategies used by the parasite to avoid these responses are major determinants of the outcome of infection. This article provides an overview of this interplay with an emphasis on autophagy.

引用

页数：11

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