PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications

被引：39

作者：

Ulisse, Salvatore ^{[1
]}

Tuccilli, Chiara ^{[1
]}

Sorrenti, Salvatore ^{[1
]}

Antonelli, Alessandro ^{[2
]}

Fallahi, Poupak ^{[2
]}

D'Armiento, Eleonora ^{[3
]}

Catania, Antonio ^{[1
]}

Tartaglia, Francesco ^{[1
]}

Amabile, Maria Ida ^{[1
]}

Giacomelli, Laura ^{[1
]}

Metere, Alessio ^{[1
]}

Cornacchini, Nicola ^{[4
]}

Pironi, Daniele ^{[1
]}

Carbotta, Giovanni ^{[1
]}

Vergine, Massimo ^{[1
]}

Monti, Massimo ^{[1
]}

Baldini, Enke ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Surg Sci, I-00161 Rome, Italy

[2] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[3] Sapienza Univ Rome, Dept Internal Med & Med Specialties, I-00161 Rome, Italy

[4] S Kliment Ohridski Univ, Dept Surg, Sofia 1504, Bulgaria

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 06期

关键词：

thyroid cancer; programmed cell death 1; programmed cell death ligand 1; diagnosis; prognosis; therapy; ENCAPSULATED FOLLICULAR VARIANT; PROGRAMMED DEATH; ASSOCIATION GUIDELINES; NUCLEAR FEATURES; IMMUNE ESCAPE; CARCINOMA; CELLS; NEOPLASM; THERAPY; MICROENVIRONMENT;

D O I：

10.3390/ijms20061405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new immunotherapy targeting the programmed cell death 1 (PD-1) receptor and its cognate ligand PD-L1 has renewed hopes of eradicating the most difficult human cancers to treat. Among these, there are the poorly differentiated and anaplastic thyroid cancers, unresponsive to all the therapies currently in use. In the present review we will summarize information regarding the expression of PD-L1 in the different thyroid cancer histotypes, its correlation with clinicopathological features, and its potential prognostic value. Then, we will evaluate the available data indicating the PD-1/PD-L1 axis as a promising target for thyroid cancer therapy.

引用

页数：15

共 92 条

[81] Galectin-3 Performance in Histologic and Cytologic Assessment of Thyroid Nodules: A Systematic Review and Meta-Analysis [J].

Trimboli, Pierpaolo ;

Virili, Camilla ;

Romanelli, Francesco ;

Crescenzi, Anna ;

Giovanella, Luca .

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (08)

[82] CTLA-4 and PD-1 Ligand Gene Expression in Epithelial Thyroid Cancers [J].

Tuccilli, Chiara ;

Baldini, Enke ;

Sorrenti, Salvatore ;

Catania, Antonio ;

Antonelli, Alessandro ;

Fallahi, Poupak ;

Tartaglia, Francesco ;

Barollo, Susi ;

Mian, Caterina ;

Palmieri, Andrea ;

Carbotta, Giovanni ;

Arcieri, Stefano ;

Pironi, Daniele ;

Vergine, Massimo ;

Monti, Massimo ;

Ulisse, Salvatore .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2018, 2018

[83] Expression and prognostic value of the cell polarity PAR complex members in thyroid cancer [J].

Tuccilli, Chiara ;

Baldini, Enke ;

Arlot-Bonnemains, Yannick ;

Chesnel, Frank ;

Sorrenti, Salvatore ;

De Vito, Corrado ;

D'Armiento, Eleonora ;

Antonelli, Alessandro ;

Fallahi, Poupak ;

Watutantrige, Sara ;

Tartaglia, Francesco ;

Barollo, Susi ;

Mian, Caterina ;

Arcieri, Stefano ;

Mascagni, Domenico ;

Pironi, Daniele ;

Bononi, Marco ;

Vergine, Massimo ;

Monti, Massimo ;

Filippini, Angelo ;

Ulisse, Salvatore .

INTERNATIONAL JOURNAL OF ONCOLOGY, 2017, 50 (04) :1413-1422

[84] PD-1 blockade induces responses by inhibiting adaptive immune resistance [J].

Tumeh, Paul C. ;

Harview, Christina L. ;

Yearley, Jennifer H. ;

Shintaku, I. Peter ;

Taylor, Emma J. M. ;

Robert, Lidia ;

Chmielowski, Bartosz ;

Spasic, Marko ;

Henry, Gina ;

Ciobanu, Voicu ;

West, Alisha N. ;

Carmona, Manuel ;

Kivork, Christine ;

Seja, Elizabeth ;

Cherry, Grace ;

Gutierrez, Antonio J. ;

Grogan, Tristan R. ;

Mateus, Christine ;

Tomasic, Gorana ;

Glaspy, John A. ;

Emerson, Ryan O. ;

Robins, Harlan ;

Pierce, Robert H. ;

Elashoff, David A. ;

Robert, Caroline ;

Ribas, Antoni .

NATURE, 2014, 515 (7528) :568-+

[85] Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules [J].

Ulisse, Salvatore ;

Bosco, Daniela ;

Nardi, Francesco ;

Nesca, Angela ;

D'Armiento, Eleonora ;

Guglielmino, Valeria ;

De Vito, Corrado ;

Sorrenti, Salvatore ;

Pironi, Daniele ;

Tartaglia, Francesco ;

Arcieri, Stefano ;

Catania, Antonio ;

Monti, Massimo ;

Filippini, Angelo ;

Ascoli, Valeria .

INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2017, 2017

[86] Anaplastic Thyroid Cancer: Outcome and the Mutation/Expression Profiles of Potential Targets [J].

Wu, Hao ;

Sun, Yue ;

Ye, Huihui ;

Yang, Shi ;

Lee, Stephanie L. ;

de las Morenas, Antonio .

PATHOLOGY & ONCOLOGY RESEARCH, 2015, 21 (03) :695-701

[87] Genomic Landscape of poorly Differentiated and Anaplastic Thyroid Carcinoma [J].

Xu, Bin ;

Ghossein, Ronald .

ENDOCRINE PATHOLOGY, 2016, 27 (03) :205-212

[88] Expression and Distribution of S-100, CD83, and Costimulatory Molecules (CD80 and CD86) in Tissues of Thyroid Papillary Carcinoma [J].

Xu, Wen-Can ;

Li, Zheng-Bing ;

Chen, Yong-Ru ;

Li, Xi-Tao ;

Huang, Jie-Xiong ;

Li, Yu-Guang ;

Chen, Shen-Ren .

CANCER INVESTIGATION, 2011, 29 (04) :286-292

[89] TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression [J].

Yang, Li ;

Pang, Yanli ;

Moses, Harold L. .

TRENDS IN IMMUNOLOGY, 2010, 31 (06) :220-227

[90] Dysfunction of natural killer cells mediated by PD-1 and Tim-3 pathway in anaplastic thyroid cancer [J].

Yin, Ming ;

Di, Gongye ;

Bian, Min .

INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 64 :333-339

← 1 2 3 4 5 6 7 8 9 10 →