PD-1 Ligand Expression in Epithelial Thyroid Cancers: Potential Clinical Implications

被引：39

作者：

Ulisse, Salvatore ^{[1
]}

Tuccilli, Chiara ^{[1
]}

Sorrenti, Salvatore ^{[1
]}

Antonelli, Alessandro ^{[2
]}

Fallahi, Poupak ^{[2
]}

D'Armiento, Eleonora ^{[3
]}

Catania, Antonio ^{[1
]}

Tartaglia, Francesco ^{[1
]}

Amabile, Maria Ida ^{[1
]}

Giacomelli, Laura ^{[1
]}

Metere, Alessio ^{[1
]}

Cornacchini, Nicola ^{[4
]}

Pironi, Daniele ^{[1
]}

Carbotta, Giovanni ^{[1
]}

Vergine, Massimo ^{[1
]}

Monti, Massimo ^{[1
]}

Baldini, Enke ^{[1
]}

机构：

[1] Sapienza Univ Rome, Dept Surg Sci, I-00161 Rome, Italy

[2] Univ Pisa, Dept Clin & Expt Med, I-56126 Pisa, Italy

[3] Sapienza Univ Rome, Dept Internal Med & Med Specialties, I-00161 Rome, Italy

[4] S Kliment Ohridski Univ, Dept Surg, Sofia 1504, Bulgaria

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 06期

关键词：

thyroid cancer; programmed cell death 1; programmed cell death ligand 1; diagnosis; prognosis; therapy; ENCAPSULATED FOLLICULAR VARIANT; PROGRAMMED DEATH; ASSOCIATION GUIDELINES; NUCLEAR FEATURES; IMMUNE ESCAPE; CARCINOMA; CELLS; NEOPLASM; THERAPY; MICROENVIRONMENT;

D O I：

10.3390/ijms20061405

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The new immunotherapy targeting the programmed cell death 1 (PD-1) receptor and its cognate ligand PD-L1 has renewed hopes of eradicating the most difficult human cancers to treat. Among these, there are the poorly differentiated and anaplastic thyroid cancers, unresponsive to all the therapies currently in use. In the present review we will summarize information regarding the expression of PD-L1 in the different thyroid cancer histotypes, its correlation with clinicopathological features, and its potential prognostic value. Then, we will evaluate the available data indicating the PD-1/PD-L1 axis as a promising target for thyroid cancer therapy.

引用

页数：15

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