Efficacy of abbreviated Stanford V chemotherapy and involved-field radiotherapy in early-stage Hodgkin lymphoma: mature results of the G4 trial

被引：21

作者：

Advani, R. H. ^{[1
]}

Hoppe, R. T. ^{[2
]}

Baer, D. ^{[3
]}

Mason, J. ^{[3
]}

Warnke, R. ^{[4
]}

Allen, J. ^{[1
]}

Daadi, S. ^{[1
]}

Rosenberg, S. A. ^{[1
]}

Horning, S. J. ^{[1
]}

机构：

[1] Stanford Univ, Dept Med Oncol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Radiat Oncol, Stanford, CA 94305 USA

[3] Northern Calif Kaiser Permanente, Dept Hematol Oncol, Oakland, CA USA

[4] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

来源：

ANNALS OF ONCOLOGY | 2013年 / 24卷 / 04期

基金：

美国国家卫生研究院;

关键词：

abbreviated Stanford V regimen; early-stage Hodgkin lymphoma; involved-field radiotherapy; FINAL ANALYSIS; RADIATION; DISEASE; INTENSIFICATION; ABVD;

D O I：

10.1093/annonc/mds542

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To assess the efficacy of an abbreviated Stanford V regimen in patients with early-stage Hodgkin lymphoma (HL). Patients with untreated nonbulky stage I-IIA supradiaphragmatic HL were eligible for the G4 study. Stanford V chemotherapy was administered for 8 weeks followed by radiation therapy (RT) 30 Gy to involved fields (IF). Freedom from progression (FFP), disease-specific survival (DSS) and overall survival (OS) were estimated. All 87 enrolled patients completed the abbreviated regimen. At a median follow-up of 10 years, FFP, DSS and OS are 94%, 99% and 94%, respectively. Therapy was well tolerated with no treatment-related deaths. Mature results of the abbreviated Stanford V regimen in nonbulky early-stage HL are excellent and comparable to the results from other contemporary therapies.

引用

页码：1044 / 1048

页数：5

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