Sleep Apnea and Stroke

被引：81

作者：

Lyons, Owen D.

Ryan, Clodagh M.

机构：

[1] Univ Toronto, Toronto Gen Hosp, Ctr Sleep Hlth & Res, Toronto, ON M5G 1L7, Canada

[2] Toronto Rehabil Inst, Toronto, ON M5G 1L7, Canada

来源：

CANADIAN JOURNAL OF CARDIOLOGY | 2015年 / 31卷 / 07期

关键词：

POSITIVE AIRWAY PRESSURE; ACUTE ISCHEMIC-STROKE; BLOOD-PRESSURE; RISK-FACTOR; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; INTERMITTENT HYPOXIA; MATRIX METALLOPROTEINASES; ENDOTHELIAL DYSFUNCTION; CEREBRAL AUTOREGULATION;

D O I：

10.1016/j.cjca.2015.03.014

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stroke is the second leading cause of death worldwide and often has devastating consequences for affected individuals in terms of chronic disability. Traditional risk factors such as age, male sex, ethnicity, hypertension, and atrial fibrillation explain 60%-80% of the risk of stroke. Obstructive sleep apnea (OSA) is highly prevalent in individuals who have had a stroke and its emerging role as a potential modifiable risk factor for stroke has been recognized in the most recent American Heart Association stroke guidelines, which recommend consideration of screening for and treatment of OSA in this regard. In this article we provide an overview of the current evidence-based knowledge related to stroke and sleep apnea. The main focus of this article is key pathophysiological mechanisms by which OSA might increase the risk for stroke. The effect of OSA on stroke outcomes and the efficacy of treatment of OSA on these outcomes is also discussed.

引用

收藏

页码：918 / 927

页数：10

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