Prospective analysis of the association between skeletal-related events and quality of life in patients with advanced lung cancer (CSP-HOR13)

被引：13

作者：

Kunikane, Hiroshi ^{[1
]}

Yokota, Isao ^{[2
]}

Katakami, Nobuyuki ^{[3
]}

Takeda, Koji ^{[4
]}

Takayama, Koichi ^{[5
]}

Sawa, Toshiyuki ^{[6
]}

Saito, Hiroshi ^{[7
]}

Harada, Masao ^{[8
]}

Yokota, Soichiro ^{[9
]}

Ando, Kiyoshi ^{[10
]}

Saito, Yuko ^{[11
]}

Ohashi, Yasuo ^{[12
]}

Eguchi, Kenji ^{[13
]}

机构：

[1] Yokohama Municipal Citizens Hosp, Dept Palliat Med, Yokohama, Kanagawa 2408555, Japan

[2] Kyoto Prefectural Univ Med, Dept Biostat, Kyoto, Kyoto 6028566, Japan

[3] Inst Biomed Res & Innovat, Div Integrated Oncol, Kobe, Hyogo 6500047, Japan

[4] Osaka City Gen Hosp, Div Med Oncol, Osaka, Osaka 5340021, Japan

[5] Kyoto Prefectural Univ Med, Dept Pulm Med, Kyoto, Kyoto 6028566, Japan

[6] Gifu Municipal Hosp, Div Resp Med & Oncol, Gifu, Gifu 5008513, Japan

[7] Aichi Hosp, Aichi Canc Ctr, Dept Resp Med, Okazaki, Aichi 4440011, Japan

[8] Natl Hosp Org Hokkaido Canc Ctr, Dept Resp Med, Sapporo, Hokkaido 0030804, Japan

[9] Toneyama Natl Hosp, Dept Resp Med, Toyonaka, Osaka 5600045, Japan

[10] Tokai Univ, Sch Med, Div Hematol Oncol, Isehara, Kanagawa 2591193, Japan

[11] Shizuoka Canc Ctr, Clin Trial Coordinat Off, Shizuoka, Shizuoka 4118777, Japan

[12] Chuo Univ, Dept Integrated Sci & Engn Sustainable Soc, Tokyo 1128551, Japan

[13] Teikyo Univ, Sch Med, Med Oncol, Tokyo 1738606, Japan

来源：

ONCOLOGY LETTERS | 2019年 / 17卷 / 01期

关键词：

lung cancer; skeletal-related event; quality of life; EuroQOL-5; dimension; functional assessment of cancer therapy-general; barthel index; ZOLEDRONIC ACID; BONE METASTASIS; DOUBLE-BLIND; SOLID TUMORS; PHASE-III; PLACEBO; MANAGEMENT; SURVIVAL; THERAPY; BREAST;

D O I：

10.3892/ol.2018.9680

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A prospective study has previously reported on the incidence of bone metastasis (BM) and skeletal-related events (SREs) in patients with advanced lung cancer. The aim of the present study was to prospectively investigate how the quality of life (QOL) of patients with advanced lung cancer was affected by SREs. Patients with stage IIIB or IV non-small cell lung cancer (NSCLC) or small cell lung cancer (SCLC) at any stage were followed up every four weeks to determine if they had developed SREs. QOL questionnaires were conducted at enrollment, at 3- and 12-months later and at 1 month after the onset of SREs, using QOL scores including the EuroQOL-5 Dimension (EQ-5D), Functional Assessment of Cancer Therapy-General (FACT-G) and activities of daily living (ADL) scores obtained by the Barthel Index. A total of 274 patients were enrolled in the study. At enrollment the EQ-5D and Barthel Index scores were lower in patients with SREs compared with patients without SREs. A chronological analysis revealed no statistically significant changes in either QOL or ADL in any of the patients. For 14 patients in whom QOL data was collected following the onset of SREs, the evaluation undertaken on the four subscales of the FACT-G revealed a significant decline in emotional functioning following the onset of SREs.

引用

页码：1320 / 1326

页数：7