Risk factors of lateral lymph node metastasis in cN0 papillary thyroid carcinoma

Background: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. Methods: We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection. Results: The rates of CLN and LLN metastases were 68.2 and 47.4%, respectively. Large tumor size (> 20 mm) had a fourfold higher risk of LLN metastasis compared with small tumor size (= 20 mm; OR = 4.082, 95% CI 2.646-6. 289; P = 0.001). Patients with tumor in the upper lobe had similar to 3-fold higher risk of LLN metastasis compared with patients with tumor in other locations (OR = 2.874, 95% CI 1.916-4.310; P = 0.001). Multifocality and extrathyroidal extension indicated a twofold higher risk of LLN metastasis. Having >= 2 CLN metastases dramatically increased the risk of LLN metastasis, compared with those with < 2 CLN metastases (OR = 6.536, 95% CI 4.630-9.259; P = 0.001). Conclusions: Large tumor size (> 20 mm), tumor located in the upper lobe, multifocality, extrathyroidal extension, and >= 2 CLN metastases may increase the risk of LLN metastasis in cN0 PTC patients.