The modern role of antipsychotics for the treatment of agitation and psychosis in Alzheimer's disease

被引：25

作者：

Creese, Byron ^{[1
]}

Da Silva, Miguel Vasconcelos ^{[1
]}

Johar, Iskandar ^{[2
]}

Ballard, Clive ^{[1
]}

机构：

[1] Univ Exeter, Sch Med, Heavitree Rd, Exeter, Devon, England

[2] Kings Coll London, Dept Old Age Psychiat, Inst Psychiat Psychol & Neurosci, London, England

来源：

EXPERT REVIEW OF NEUROTHERAPEUTICS | 2018年 / 18卷 / 06期

关键词：

Agitation; Alzheimer's disease; atypical antipsychotics; dementia; psychosis; NEUROPSYCHIATRIC SYMPTOMS; BEHAVIORAL SYMPTOMS; DOUBLE-BLIND; ATYPICAL ANTIPSYCHOTICS; TAU PHOSPHORYLATION; COST-EFFECTIVENESS; RANDOMIZED-TRIAL; DEMENTIA CARE; PLACEBO; EFFICACY;

D O I：

10.1080/14737175.2018.1476140

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction: Antipsychotics have long been the mainstay of treatment for agitation and psychosis in Alzheimer's disease. Despite their current use successive studies have shown that they only confer a modest benefit which must be balanced against their well-established serious side effects (extrapyramidal symptoms, stroke, accelerated cognitive decline and mortality).Areas covered: This review outlines the current guidance on antipsychotic usage and the evidence of their continued usage against a backdrop of emerging pharmacological treatments and an increasing emphasis on the importance of non-pharmacological interventions.Expert commentary: The current justification for antipsychotic use in the context of the changing landscape of prescribing and provide a view on the most promising alternative candidates to this class of drug are appraised.

引用

页码：461 / 467

页数：7

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