Redox-Neutral Cyanoalkylation/Cyclization of Olefinic 1,3-Dicarbonyls with Cycloketone Oxime Esters: Access to Cyanoalkylated Dihydrofurans

被引：57
作者：
Zhang, Jia-Yu
Duan, Xin-Hua
Yang, Jun-Cheng
Guo, Li-Na [1 ]
机构：
[1] Xi An Jiao Tong Univ, Sch Sci, Dept Chem, Xian 710049, Shaanxi, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 07期
关键词：
CYCLOBUTANONE O-BENZOYLOXIMES; C-H CYANOALKYLATION; RING-CLEAVAGE; IMINYL RADICALS; CYCLIZATION; ALKENES; NITRILES; 2,3-DIHYDROFURANS; DERIVATIVES; IMIDATION;
D O I：
10.1021/acs.joc.8b00271
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Metal-catalyzed cyanoalkylation/cyclization of olefinic 1,3-dicarbonyls with cydoketone oxime esters has been developed under redox-neutral conditions. This protocol provided a straightforward approach to diverse cyanoalkylated 2,3-dihydrofurans via a tandem ring-opening/addition/cyclization process.
引用
收藏
页码：4239 / 4249
页数：11
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