A comprehensive review on regulatory effects of crocin on ischemia/reperfusion injury in multiple organs

被引：28
作者：
Akbari, Ghaidafeh [1 ,2 ]
Mard, Seyyed ali [2 ]
Veisi, Ali [3 ]
机构：
[1] Yasuj Univ Med Sci, Yasuj, Iran
[2] Ahvaz Jundishapur Univ Med Sci, Sch Med, Dept Physiol,PRC, Res Ctr Infect Dis Digest Syst,Alimentary Tract R, Ahvaz, Iran
[3] Behbahan Fac Med Sci, Behbahan, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2018年 / 99卷
关键词：
Ischemia/reperfusion injury; Crocin; Review; Multiple organs; ISCHEMIA-REPERFUSION INJURY; INDUCED OXIDATIVE/NITRATIVE INJURY; HEPATIC ISCHEMIA; SAFFRON EXTRACT; SATIVUS L; RAT MODEL; CEREBRAL MICROVESSELS; HEPATORENAL-SYNDROME; ACTIVE CONSTITUENT; OXIDATIVE STRESS;
D O I：
10.1016/j.biopha.2018.01.113
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ischemia-reperfusion (I/R) injury affects o(2)-dependent organs including liver, kidneys, heart, brain, and intestine. I/R injury is described as the cellular injury in an organ caused by ischemia and then further aggravated during the reperfusion due to intracellular alterations. It is a process that happens in clinical settings such as organ transplantation, reperfusion after thrombolytic therapy, and coronary angioplasty. Crocus sativus L. known as saffron used in folk medicine for its beneficial effects. It contains multiple bioactive compounds including the crocin, crocetin, picrocrocin, and safranal. Crocin, a water-soluble carotenoid has antitumor, radical scavenging, anti hyperlipidemia and memory improving effects. Moreover, crocin has antioxidant, and protective effects on I/R models in rats at various organs such as heart, brain, kidney, stomach, liver, and kidney as described in detail in this review.
引用
收藏
页码：664 / 670
页数：7
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