Is early-life iron exposure critical in neurodegeneration?

被引:85
作者
Hare, Dominic J. [1 ]
Arora, Manish [2 ]
Jenkins, Nicole L. [3 ]
Finkelstein, David I. [3 ]
Doble, Philip A. [1 ]
Bush, Ashley I. [3 ]
机构
[1] Univ Technol Sydney, Elemental Bioimaging Facil, Ultimo, NSW 2007, Australia
[2] Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA
[3] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3052, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
BREAST-FED INFANTS; BLOOD-BRAIN-BARRIER; HUMAN-MILK; ALZHEIMERS-DISEASE; DEFICIENCY ANEMIA; SUBSTANTIA-NIGRA; TRACE-ELEMENTS; DIETARY IRON; NEUROBEHAVIORAL DYSFUNCTIONS; DEVELOPMENTAL-CHANGES;
D O I
10.1038/nrneurol.2015.100
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The effects of iron deficiency are well documented, but relatively little is known about the long-term implications of iron overload during development. High levels of redox-active iron in the brain have been associated with neurodegenerative disorders, most notably Parkinson disease, yet a gradual increase in brain iron seems to be a feature of normal ageing. Increased brain iron levels might result from intake of infant formula that is excessively fortified with iron, thereby altering the trajectory of brain iron uptake and amplifying the risk of iron-associated neurodegeneration in later life. In this Perspectives article, we discuss the potential long-term implications of excessive iron intake in early life, propose the analysis of iron deposits in teeth as a method for retrospective determination of iron exposure during critical developmental windows, and call for evidence-based optimization of the chemical composition of infant dietary supplements.
引用
收藏
页码:536 / 544
页数:9
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