Translational studies on regulation of brain docosahexaenoic acid (DHA) metabolism in vivo

被引：33
作者：
Rapoport, Stanley I. [1 ]
机构：
[1] NIA, Brain Physiol & Metab Sect, NIH, Bethesda, MD 20892 USA
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2013年 / 88卷 / 01期
关键词：
ALPHA-LINOLENIC ACID; CYTOSOLIC PHOSPHOLIPASE A(2); POLYUNSATURATED FATTY-ACIDS; ARACHIDONIC-ACID; ALZHEIMERS-DISEASE; NUTRITIONAL DEPRIVATION; SIGNAL-TRANSDUCTION; LIVER CONVERSION; RAT; PLASMA;
D O I：
10.1016/j.plefa.2012.05.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One goal in the field of brain polyunsaturated fatty acid (PUFA) metabolism is to translate the many studies that have been conducted in vitro and in animal models to the clinical setting. Doing so should elucidate the role of PUFAs in the human brain, and effects of diet, drugs, disease and genetics on this role. This review discusses new in vivo radiotracer kinetic and neuroimaging techniques that allow us to do this, with a focus on docosahexaenoic acid (DHA). We illustrate how brain PUFA metabolism is influenced by graded reductions in dietary n-3 PUFA content in unanesthetized rats. We also show how kinetic tracer techniques in rodents have helped to identify mechanisms of action of mood stabilizers used in bipolar disorder, how DHA participates in neurotransmission, and how brain DHA metabolism is regulated by calcium-independent iPLA(2)beta. In humans, regional rates of brain DHA metabolism can be quantitatively imaged with positron emission tomography following intravenous injection of [1-C-11]DHA. Published by Elsevier Ltd.
引用
收藏
页码：79 / 85
页数：7
相关论文
共 81 条
[1]   Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null mice [J].
Bao, Shunzhong ;
Jacobson, David A. ;
Wohltmann, Mary ;
Bohrer, Alan ;
Jin, Wu ;
Philipson, Louis H. ;
Turk, John .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2008, 294 (02) :E217-E229
[2]  
Basselin M, 2011, BRAIN RES B
[3]   Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats [J].
Basselin, Mireille ;
Chang, Lisa ;
Bell, Jane M. ;
Rapoport, Stanley I. .
NEUROPSYCHOPHARMACOLOGY, 2006, 31 (08) :1659-1674
[4]   Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice [J].
Basselin, Mireille ;
Rosa, Angelo O. ;
Ramadan, Epolia ;
Cheon, Yewon ;
Chang, Lisa ;
Chen, Mei ;
Greenstein, Deanna ;
Wohltmann, Mary ;
Turk, John ;
Rapoport, Stanley I. .
JOURNAL OF LIPID RESEARCH, 2010, 51 (11) :3166-3173
[5]   Cytosolic phospholipase A(2) is coupled to muscarinic receptors in the human astrocytoma cell line 1321N1: Characterization of the transducing mechanism [J].
Bayon, Y ;
Hernandez, M ;
Alonso, A ;
Nunez, L ;
GarciaSancho, J ;
Leslie, C ;
Crespo, MS ;
Nieto, ML .
BIOCHEMICAL JOURNAL, 1997, 323 :281-287
[6]   Omega-3 fatty acids, pro-inflammatory signaling and neuroprotection [J].
Bazan, Nicolas G. .
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2007, 10 (02) :136-141
[7]   Cellular and molecular events mediated by docosahexaenoic acid-derived neuroprotectin D1 signaling in photoreceptor cell survival and brain protection [J].
Bazan, Nicolas G. .
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 2009, 81 (2-3) :205-211
[8]   Interactions between effectors linked to serotonin receptors [J].
Berg, KA ;
Maayani, S ;
Clarke, WP .
ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICS, 1998, 861 :111-120
[9]   DIETARY ALPHA-LINOLENIC ACID AT 1.3 G/KG MAINTAINS MAXIMAL DOCOSAHEXAENOIC ACID CONCENTRATION IN BRAIN, HEART AND LIVER OF ADULT-RATS [J].
BOURRE, JM ;
DUMONT, O ;
PASCAL, G ;
DURAND, G .
JOURNAL OF NUTRITION, 1993, 123 (07) :1313-1319
[10]   THE EFFECTS OF DIETARY ALPHA-LINOLENIC ACID ON THE COMPOSITION OF NERVE MEMBRANES, ENZYMATIC-ACTIVITY, AMPLITUDE OF ELECTROPHYSIOLOGICAL PARAMETERS, RESISTANCE TO POISONS AND PERFORMANCE OF LEARNING-TASKS IN RATS [J].
BOURRE, JM ;
FRANCOIS, M ;
YOUYOU, A ;
DUMONT, O ;
PICIOTTI, M ;
PASCAL, G ;
DURAND, G .
JOURNAL OF NUTRITION, 1989, 119 (12) :1880-1892
123456789