Ghrelin as a starvation signal

被引：8
作者：
Date, Yukari [1 ]
Kangawa, Kenji [2 ]
机构：
[1] Miyazaki Univ, Frontier Sci Res Ctr, Miyazaki 8891692, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan
来源：
OBESITY RESEARCH & CLINICAL PRACTICE | 2012年 / 6卷 / 04期
关键词：
Ghrelin; GHS-R; Feeding; Vagus nerve; GROWTH-HORMONE RELEASE; ACTIVATED PROTEIN-KINASE; GLUCAGON-LIKE PEPTIDE-1; DES-ACYL GHRELIN; FOOD-INTAKE; CIRCULATING GHRELIN; PRADER-WILLI; VAGAL NERVE; WEIGHT-LOSS; PITUITARY;
D O I：
10.1016/j.orcp.2012.08.195
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin, a gastrointestinal hormone, functions as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). It comprises 28 amino acids, of which the Ser-3 residue is post-translationally modified by the addition of octanoyl acid. Ghrelin stimulates feeding and the secretion of growth hormone; it is also thought to function in energy conservation. Here, we provide an overview of the discovery of ghrelin, its pathophysiological significance, and the mechanism of ghrelin-induced feeding. (C) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：E263 / E269
页数：7
相关论文
共 50 条
  • [31] Ghrelin and cancer
    Chopin, Lisa
    Walpole, Carina
    Seim, Inge
    Cunningham, Peter
    Murray, Rachael
    Whiteside, Eliza
    Josh, Peter
    Herington, Adrian
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2011, 340 (01) : 65 - 69
  • [32] Relationship between Orexigenic Peptide Ghrelin Signal, Gender Difference and Disease
    Yamada, Chihiro
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (07)
  • [33] Changes in ghrelin and ghrelin receptor expression according to feeding status
    Kim, MS
    Yoon, CY
    Park, KH
    Shin, CS
    Park, KS
    Kim, SY
    Cho, BY
    Lee, HK
    NEUROREPORT, 2003, 14 (10) : 1317 - 1320
  • [34] Ghrelin, des-acyl ghrelin and obestatin on the gastrointestinal motility
    Fujimiya, Mineko
    Ataka, Koji
    Asakawa, Akihiro
    Chen, Chih-Yen
    Kato, Ikuo
    Inui, Akio
    PEPTIDES, 2011, 32 (11) : 2348 - 2351
  • [35] Ghrelin: more than endogenous growth hormone secretagogue
    Kojima, Masayasu
    Kangawa, Kenji
    PHYLOGENETIC ASPECTS OF NEUROPEPTIDES: FROM INVERTEBRATES TO HUMANS, 2010, 1200 : 140 - 148
  • [36] Physiological role of ghrelin as revealed by the ghrelin and GOAT knockout mice
    Kang, Kihwa
    Zmuda, Erik
    Sleeman, Mark W.
    PEPTIDES, 2011, 32 (11) : 2236 - 2241
  • [37] Physiological roles revealed by ghrelin and ghrelin receptor deficient mice
    Albarran-Zeckler, Rosie G.
    Sun, Yuxiang
    Smith, Roy G.
    PEPTIDES, 2011, 32 (11) : 2229 - 2235
  • [38] Revisiting the Ghrelin Changes Following Bariatric and Metabolic Surgery
    Tuero, Carlota
    Valenti, Victor
    Rotellar, Fernando
    Landecho, Manuel F.
    Cienfuegos, Javier A.
    Fruhbeck, Gema
    OBESITY SURGERY, 2020, 30 (07) : 2763 - 2780
  • [39] A skeleton in the cupboard in ghrelin research: Where are the skinny dwarfs?
    Peris-Sampedro, Fiona
    Le May, Marie, V
    Stoltenborg, Iris
    Schele, Erik
    Dickson, Suzanne L.
    JOURNAL OF NEUROENDOCRINOLOGY, 2021, 33 (11)
  • [40] The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin's biological interactions and avenues for controlling ghrelin signaling
    Cleverdon, Elizabeth R.
    McGovern-Gooch, Kayleigh R.
    Hougland, James L.
    MOLECULAR MEMBRANE BIOLOGY, 2016, 33 (6-8) : 111 - 124
12345