Ghrelin as a starvation signal

被引：8
作者：
Date, Yukari [1 ]
Kangawa, Kenji [2 ]
机构：
[1] Miyazaki Univ, Frontier Sci Res Ctr, Miyazaki 8891692, Japan
[2] Natl Cerebral & Cardiovasc Ctr, Res Inst, Osaka 5658565, Japan
来源：
OBESITY RESEARCH & CLINICAL PRACTICE | 2012年 / 6卷 / 04期
关键词：
Ghrelin; GHS-R; Feeding; Vagus nerve; GROWTH-HORMONE RELEASE; ACTIVATED PROTEIN-KINASE; GLUCAGON-LIKE PEPTIDE-1; DES-ACYL GHRELIN; FOOD-INTAKE; CIRCULATING GHRELIN; PRADER-WILLI; VAGAL NERVE; WEIGHT-LOSS; PITUITARY;
D O I：
10.1016/j.orcp.2012.08.195
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Ghrelin, a gastrointestinal hormone, functions as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R). It comprises 28 amino acids, of which the Ser-3 residue is post-translationally modified by the addition of octanoyl acid. Ghrelin stimulates feeding and the secretion of growth hormone; it is also thought to function in energy conservation. Here, we provide an overview of the discovery of ghrelin, its pathophysiological significance, and the mechanism of ghrelin-induced feeding. (C) 2012 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：E263 / E269
页数：7
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